Hand2 (Mus musculus)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSMUSG00000038193 T035721_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables protein homodimerization activity and sequence-specific DNA binding activity. Contributes to E-box binding activity. Involved in several processes, including heart morphogenesis; negative regulation of cardiac muscle cell apoptotic process; and positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis. Acts upstream of or within several processes, including animal organ development; negative regulation of osteoblast differentiation; and nervous system development. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; heart; and hindlimb phalanx. Orthologous to human HAND2 (heart and neural crest derivatives expressed 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HAND2
M04150_2.00 		Homo sapiens
MACACCTGBD
HVCAGGTGTK		 SELEX
Yin et al.(2017)
HAND2_eDBD_HT-SELEX 		0.914 1.000
HAND2
M04151_2.00 		Homo sapiens
MACACCTGYD
HRCAGGTGTK		 SELEX
Yin et al.(2017)
HAND2_eDBD_Methyl-HT-SELEX 		0.914 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000044983 bHLH 100 152

Links

Other bHLH family TFs
Other Mus musculus TFs

Invalid Input OrderBy

101 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action