Arntl2 (Mus musculus)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSMUSG00000040187 T035726_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (Per, Arnt, Sim) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian Clock protein, the structurally related Mop4, and hypoxia-inducible factors, such as Hif1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000079373 bHLH 49 102
ENSMUSP00000107263 bHLH 49 102
ENSMUSP00000107265 bHLH 49 102
ENSMUSP00000107266 bHLH 49 102
ENSMUSP00000121170 bHLH 49 102

Links

Other bHLH family TFs
Other Mus musculus TFs

2 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Arntl2 Rattus norvegicus ENSRNOG00000001830 N 0.882