Hes5 (Mus musculus)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSMUSG00000048001 T035739_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including nervous system development; positive regulation of signal transduction; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including nephron morphogenesis; nervous system development; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; paraxial mesenchyme; sensory organ; small intestine; and urinary system. Orthologous to human HES5 (hes family bHLH transcription factor 5). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Hes5
M01747_2.00		 Mus musculus
NVCRCGYGBN
NVCRCGYGBN		 PBM
Weirauch et al.(2014)
pTH5450		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HES5
M02809_2.00 		Homo sapiens
YGRCACGTGCCD
HGGCACGTGYCR		 SELEX
Jolma et al.(2013)
HES5_1 		0.914 1.000
HES5
M02810_2.00 		Homo sapiens
YGGCACGTGCCR
YGGCACGTGCCR		 SELEX
Jolma et al.(2013)
HES5_2 		0.914 1.000
HES5
M04216_2.00 		Homo sapiens
VRCACGTGCC
GGCACGTGYB		 SELEX
Yin et al.(2017)
HES5_eDBD_HT-SELEX 		0.914 1.000
HES5
M04217_2.00 		Homo sapiens
VRCACGTGCC
GGCACGTGYB		 SELEX
Yin et al.(2017)
HES5_eDBD_Methyl-HT-SELEX_1 		0.914 1.000
HES5
M04218_2.00 		Homo sapiens
VSACRCKY
RMGYGTSB		 SELEX
Yin et al.(2017)
HES5_eDBD_Methyl-HT-SELEX_2 		0.914 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01747_2.00 bHLH 17 73

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000051118 bHLH 17 73

Links

Other bHLH family TFs
Other Mus musculus TFs

28 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSMMUG00000014688 Macaca mulatta ENSMMUG00000014688 I 0.914
Hes5 Rattus norvegicus ENSRNOG00000013850 I 0.914
HES5 Gorilla gorilla ENSGGOG00000010276 I 0.914
HES5 Pan troglodytes ENSPTRG00000024233 I 0.914
ENSOARG00000018071 Ovis aries ENSOARG00000018071 I 0.914
ENSPANG00000022730 Papio anubis ENSPANG00000022730 I 0.914
HES5 Otolemur garnettii ENSOGAG00000030950 I 0.914
HES5 Procavia capensis ENSPCAG00000001025 I 0.914
HES5 Tursiops truncatus ENSTTRG00000003782 I 0.914
HES5 Callithrix jacchus ENSCJAG00000002549 I 0.914
HES5 Canis familiaris ENSCAFG00000019421 I 0.914
HES5 Bos taurus ENSBTAG00000002483 I 0.914
ENSCPOG00000027139 Cavia porcellus ENSCPOG00000027139 I 0.914
ENSCSAG00000000715 Chlorocebus sabaeus ENSCSAG00000000715 I 0.914
HES5 Homo sapiens ENSG00000197921 D 0.914
HES5 Erinaceus europaeus ENSEEUG00000008377 I 0.914
ENSSHAG00000014397 Sarcophilus harrisii ENSSHAG00000014397 I 0.884
HES5 Monodelphis domestica ENSMODG00000008212 I 0.884
ENSMEUG00000013913 Macropus eugenii ENSMEUG00000013913 I 0.884
Alligator_sinensis_CCG011591.1 Alligator sinensis Alligator_sinensis_CCG011591.1 I 0.860
Brh_R011663 Buceros rhinoceros Brh_R011663 I 0.860
Afo_R003314 Aptenodytes forsteri Afo_R003314 I 0.860
Tal_R007855 Tyto alba Tal_R007855 I 0.860
Aan_R005913 Calypte anna Aan_R005913 I 0.860
HES5 Meleagris gallopavo ENSMGAG00000002009 I 0.860
HES5 Gallus gallus ENSGALG00000001141 I 0.860
ENSAPLG00000007967 Anas platyrhynchos ENSAPLG00000007967 I 0.860
ENSBTAP00000003221-D1 Bos grunniens ENSBTAP00000003221-D1 I 0.433