Bhlha15 (Mus musculus)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSMUSG00000052271 T035744_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in cellular response to glucose starvation; endoplasmic reticulum unfolded protein response; and negative regulation of myotube differentiation. Acts upstream of or within several processes, including glucose homeostasis; intracellular distribution of mitochondria; and mitochondrial calcium ion transmembrane transport. Located in nucleus. Is expressed in alimentary system; early conceptus; genitourinary system; and limb mesenchyme. Orthologous to human BHLHA15 (basic helix-loop-helix family member a15). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Bhlha15
M01749_2.00		 Mus musculus
RCATATGS
SCATATGY		 PBM
Weirauch et al.(2014)
pTH4582		 (Direct) (Direct)
Bhlha15
M08774_2.00		 Mus musculus
VVRRCAGCTGK
MCAGCTGYYBB		 Misc
Kulakovskiy et al.(2013)
BHA15_MOUSE.H11MO.0.A		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
BHLHA15
M02803_2.00 		Homo sapiens
AMCATATGKH
DMCATATGKT		 SELEX
Jolma et al.(2013)
BHLHA15_1 		0.914 1.000
BHLHA15
M04195_2.00 		Homo sapiens
VVCAGCTGBN
NVCAGCTGBB		 SELEX
Yin et al.(2017)
BHLHA15_eDBD_HT-SELEX_1 		0.914 1.000
BHLHA15
M04196_2.00 		Homo sapiens
NVCATATGBN
NVCATATGBN		 SELEX
Yin et al.(2017)
BHLHA15_eDBD_HT-SELEX_2 		0.914 1.000
BHLHA15
M08739_2.00 		Homo sapiens
VVRRCAGCTGK
MCAGCTGYYBB		 Misc
Kulakovskiy et al.(2013)
BHA15_HUMAN.H11MO.0.B 		0.914 1.000
BHLHA15
M04197_2.00 		Homo sapiens
VVCAGCTGKB
VMCAGCTGBB		 SELEX
Yin et al.(2017)
BHLHA15_eDBD_Methyl-HT-SELEX_1 		0.914 1.000
BHLHA15
M04198_2.00 		Homo sapiens
DVCATATGBH
DVCATATGBH		 SELEX
Yin et al.(2017)
BHLHA15_eDBD_Methyl-HT-SELEX_2 		0.914 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01749_2.00 bHLH 16 68

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000055493 bHLH 73 125

Links

Other bHLH family TFs
Other Mus musculus TFs

Invalid Input OrderBy

52 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action