Max (Mus musculus)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSMUSG00000059436 T035748_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; lens; limb cartilage condensation; and liver. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Orthologous to human MAX (MYC associated factor X). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Max
M00121_2.00		 Mus musculus
NCRCRTGNN
NNCAYGYGN		 PBM
Badis et al.(2009)
Max_3863		 (Direct) (Direct)
Max
M00122_2.00		 Mus musculus
NNCRCRTGN
NCAYGYGNN		 PBM
Badis et al.(2009)
Max_3864		 (Direct) (Direct)
Max
M01753_2.00		 Mus musculus
NCAYGYKNN
NNMRCRTGN		 PBM
Weirauch et al.(2014)
pTH4381		 (Direct) (Direct)
Max
M08778_2.00		 Mus musculus
VVVCACGYGSN
NSCRCGTGBBB		 Misc
Kulakovskiy et al.(2013)
MAX_MOUSE.H11MO.0.A		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
MAX
M00938_2.00 		Homo sapiens
CCACGTGH
DCACGTGG		 PBM
Guo et al.(2014)
Max_L 		0.914 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00121_2.00 bHLH 24 75
M00122_2.00 bHLH 24 75
M01753_2.00 bHLH 16 67

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000080778 bHLH 15 66
ENSMUSP00000106025 bHLH 24 75

Links

Other bHLH family TFs
Other Mus musculus TFs

Invalid Input OrderBy

114 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action