CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Tfe3
(
Rattus norvegicus
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSRNOG00000009605
T037189_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including negative regulation of cold-induced thermogenesis; positive regulation of brown fat cell differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription, DNA-templated and regulation of osteoclast differentiation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human TFE3 (transcription factor binding to IGHM enhancer 3). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Tfe3
M01715_2.00
Mus musculus
NCDCRTGAYN
NRTCAYGHGN
PBM
Weirauch et al.(2014)
pTH5057
0.914
1.000
Tfe3
M05833_2.00
Mus musculus
CACGTGAY
RTCACGTG
SMiLE-seq
Isakova et al.(2017)
TFE3
0.914
1.000
Tfe3
M08743_2.00
Mus musculus
TCACGTGACH
DGTCACGTGA
Misc
Kulakovskiy et al.(2013)
TFE3_MOUSE.H11MO.0.A
0.914
1.000
Tfe3
M09884_2.00
Mus musculus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TFEA_01
0.914
1.000
Mitf
M01741_2.00
Mus musculus
NCDCGTGAYN
NRTCACGHGN
PBM
Weirauch et al.(2014)
pTH5465
0.914
0.981
MITF
M08058_2.00
Homo sapiens
NNNDRTCACGTGAYHNNN
NNNDRTCACGTGAYHNNN
ChIP-seq
Mathelier et al.(2014)
MA0620.2
0.914
0.981
MITF
M08740_2.00
Homo sapiens
YCAYGTGACH
DGTCACRTGR
Misc
Kulakovskiy et al.(2013)
MITF_HUMAN.H11MO.0.A
0.914
0.981
Mitf
M08765_2.00
Mus musculus
BCHYGTGACY
RGTCACRDGV
Misc
Kulakovskiy et al.(2013)
MITF_MOUSE.H11MO.0.A
0.914
0.981
Mitf
M09475_2.00
Mus musculus
GTCACRWGVB
VBCWYGTGAC
Misc
Heinz et al.(2010)
MastCells-MITF_GSE48085
0.914
0.981
MITF
M09880_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MITF_Q4
0.914
0.981
MITF
M09881_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MITF_Q6
0.914
0.981
TFE3
M02773_2.00
Homo sapiens
VNCACGTGMY
RKCACGTGNB
SELEX
Jolma et al.(2013)
TFE3_1
0.871
0.981
TFE3
M04058_2.00
Homo sapiens
YVCACGTGAYN
NRTCACGTGBR
SELEX
Yin et al.(2017)
TFE3_eDBD_HT-SELEX
0.871
0.981
TFE3
M08709_2.00
Homo sapiens
TCACGTGACH
DGTCACGTGA
Misc
Kulakovskiy et al.(2013)
TFE3_HUMAN.H11MO.0.B
0.871
0.981
TFE3
M09790_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TFEA_Q6
0.871
0.981
TFE3
M04059_2.00
Homo sapiens
NRTCACATGBB
VVCATGTGAYN
SELEX
Yin et al.(2017)
TFE3_eDBD_Methyl-HT-SELEX
0.871
0.981
Tfec
M00755_2.00
Mus musculus
NNCACGTGNN
NNCACGTGNN
PBM
Weirauch et al.(2013)
pTH2885
0.870
0.907
Tfec
M01736_2.00
Mus musculus
NCNCRTGVYN
NRBCAYGNGN
PBM
Weirauch et al.(2014)
pTH5065
0.870
0.907
TFEC
M02778_2.00
Homo sapiens
RNCACRTGAB
VTCAYGTGNY
SELEX
Jolma et al.(2013)
TFEC_1
0.870
0.889
TFEC
M04078_2.00
Homo sapiens
NVCACGTGACN
NGTCACGTGBN
SELEX
Yin et al.(2017)
TFEC_eDBD_HT-SELEX
0.870
0.889
TFEC
M04079_2.00
Homo sapiens
VNCATGTGAYN
NRTCACATGNB
SELEX
Yin et al.(2017)
TFEC_eDBD_Methyl-HT-SELEX
0.870
0.889
Tfeb
M01728_2.00
Mus musculus
CWCGTGAY
RTCACGWG
PBM
Weirauch et al.(2014)
pTH5072
0.855
0.870
TFEB
M02781_2.00
Homo sapiens
RNCACGTGAY
RTCACGTGNY
SELEX
Jolma et al.(2013)
TFEB_1
0.855
0.870
TFEB
M02727_2.00
Homo sapiens
RTCACGTGAY
RTCACGTGAY
SELEX
Jolma et al.(2010)
TFEB_dimer
0.855
0.870
TFEB
M04088_2.00
Homo sapiens
YVCACGTGAYN
NRTCACGTGBR
SELEX
Yin et al.(2017)
TFEB_eDBD_HT-SELEX
0.855
0.870
TFEB
M08718_2.00
Homo sapiens
CACGTGAYY
RRTCACGTG
Misc
Kulakovskiy et al.(2013)
TFEB_HUMAN.H11MO.0.C
0.855
0.870
Tfeb
M08753_2.00
Mus musculus
CACGTGAYY
RRTCACGTG
Misc
Kulakovskiy et al.(2013)
TFEB_MOUSE.H11MO.0.C
0.855
0.870
TFEB
M04089_2.00
Homo sapiens
VNCATGTGAYN
NRTCACATGNB
SELEX
Yin et al.(2017)
TFEB_eDBD_Methyl-HT-SELEX
0.855
0.870
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSRNOP00000012830
bHLH
346
399
KKDNHNLIERRRRFNINDRIKELGTLIPKSNDPEMRWNKGTILKASVDYIRKLQ
Links
Other
bHLH
family TFs
Other
Rattus norvegicus
TFs
242 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy