TF Information

Hes5 *(Rattus norvegicus)* bHLH
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00010 (HLH)	IPR001092	ENSRNOG00000013850	T037205_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: Enables chromatin binding activity and double-stranded DNA binding activity. Involved in several processes, including generation of neurons; negative regulation of cell differentiation; and neuronal stem cell population maintenance. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human HES5 (hes family bHLH transcription factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
No direct experiments
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Hes5 M01747_2.00	Mus musculus	NVCRCGYGBN	NVCRCGYGBN	PBM Weirauch et al.(2014) pTH5450	0.914	1.000
HES5 M02809_2.00	Homo sapiens	YGRCACGTGCCD	HGGCACGTGYCR	SELEX Jolma et al.(2013) HES5_1	0.914	1.000
HES5 M02810_2.00	Homo sapiens	YGGCACGTGCCR	YGGCACGTGCCR	SELEX Jolma et al.(2013) HES5_2	0.914	1.000
HES5 M04216_2.00	Homo sapiens	VRCACGTGCC	GGCACGTGYB	SELEX Yin et al.(2017) HES5_eDBD_HT-SELEX	0.914	1.000
HES5 M04217_2.00	Homo sapiens	VRCACGTGCC	GGCACGTGYB	SELEX Yin et al.(2017) HES5_eDBD_Methyl-HT-SELEX_1	0.914	1.000
HES5 M04218_2.00	Homo sapiens	VSACRCKY	RMGYGTSB	SELEX Yin et al.(2017) HES5_eDBD_Methyl-HT-SELEX_2	0.914	1.000
For this family, TFs with SR scores > 0.838* will likely have a similar motif*