CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Heyl
(
Rattus norvegicus
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSRNOG00000015318
T037213_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable several functions, including AF-1 domain binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and protein homodimerization activity. Predicted to be involved in several processes, including heart development; negative regulation of androgen receptor signaling pathway; and regulation of transcription, DNA-templated. Predicted to act upstream of or within animal organ development; cellular response to BMP stimulus; and negative regulation of gene expression. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human HEYL (hes related family bHLH transcription factor with YRPW motif like). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Hey2
M01722_2.00
Mus musculus
RCACGTGNN
NNCACGTGY
PBM
Weirauch et al.(2014)
pTH5102
0.870
0.927
HEY2
M02790_2.00
Homo sapiens
GRCACGTGNV
BNCACGTGYC
SELEX
Jolma et al.(2013)
HEY2_1
0.870
0.927
HEY2
M02791_2.00
Homo sapiens
GVCACGTGYN
NRCACGTGBC
SELEX
Jolma et al.(2013)
HEY2_2
0.870
0.927
HEY2
M04131_2.00
Homo sapiens
NVCRCGYGVN
NBCRCGYGBN
SELEX
Yin et al.(2017)
HEY2_eDBD_HT-SELEX
0.870
0.927
HEY2
M04133_2.00
Homo sapiens
NVCACGTGVN
NBCACGTGBN
SELEX
Yin et al.(2017)
HEY2_FL_HT-SELEX
0.870
0.927
HEY2
M04132_2.00
Homo sapiens
NVCRCGYRVN
NBYRCGYGBN
SELEX
Yin et al.(2017)
HEY2_eDBD_Methyl-HT-SELEX
0.870
0.927
HEY2
M04134_2.00
Homo sapiens
NVCRCGYGSN
NSCRCGYGBN
SELEX
Yin et al.(2017)
HEY2_FL_Methyl-HT-SELEX
0.870
0.927
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSRNOP00000020928
bHLH
44
99
RKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLH
Links
Other
bHLH
family TFs
Other
Rattus norvegicus
TFs
167 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy