ase (Drosophila melanogaster)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 FBgn0000137 T038387_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA binding activity; protein heterodimerization activity; and protein homodimerization activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including Malpighian tubule development; generation of neurons; and negative regulation of mitotic nuclear division. Located in nucleus. Is expressed in several structures, including extended germ band embryo; head; imaginal disc; presumptive embryonic/larval nervous system; and somatic precursor cell. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ase
M05903_2.00		 Drosophila melanogaster
CACCTGY
RCAGGTG		 B1H
Zhu et al.(2011)
ase_da_SANGER_10_FBgn0000137		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0070074 bHLH 162 224

Links

Other bHLH family TFs
Other Drosophila melanogaster TFs

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17 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action