E(spl)m8-HLH (Drosophila melanogaster)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 FBgn0000591 T038390_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; protein dimerization activity; and sequence-specific DNA binding activity. Involved in several processes, including dendrite morphogenesis; mesoderm development; and sensory organ development. Predicted to be active in nucleus. Is expressed in several structures, including anterior-posterior subdivision of organism; extended germ band embryo; germ layer; neuroblasts; and presumptive embryonic/larval central nervous system. Orthologous to human HES2 (hes family bHLH transcription factor 2) and HES6 (hes family bHLH transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
E(spl)m8-HLH
M05934_2.00		 Drosophila melanogaster
GCACGTGCCR
YGGCACGTGC		 B1H
Zhu et al.(2011)
E_spl_SANGER_5_FBgn0000591		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0084335 bHLH 11 66

Links

Other bHLH family TFs
Other Drosophila melanogaster TFs

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12 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action