E(spl)m5-HLH (Drosophila melanogaster)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 FBgn0002631 T038395_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; protein dimerization activity; and sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including anterior ectoderm anlage; blastoderm embryo; embryonic segment; extended germ band embryo; and germ layer. Orthologous to human HES2 (hes family bHLH transcription factor 2); HES5 (hes family bHLH transcription factor 5); and HES6 (hes family bHLH transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
E(spl)m5-HLH
M05940_2.00
Drosophila melanogaster
SCACGHGHCA

TGDCDCGTGS
B1H
Zhu et al.(2011)
HLHm5_FlyReg_FBgn0002631
(Direct) (Direct)
E(spl)m5-HLH
M05941_2.00
Drosophila melanogaster
RRCACGTGCCA

TGGCACGTGYY
B1H
Zhu et al.(2011)
HLHm5_SANGER_5_FBgn0002631
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0084352 bHLH 19 73

Links

Other bHLH family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

23 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action