CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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E(spl)m5-HLH
(
Drosophila melanogaster
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
FBgn0002631
T038395_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; protein dimerization activity; and sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including anterior ectoderm anlage; blastoderm embryo; embryonic segment; extended germ band embryo; and germ layer. Orthologous to human HES2 (hes family bHLH transcription factor 2); HES5 (hes family bHLH transcription factor 5); and HES6 (hes family bHLH transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
E(spl)m5-HLH
M05940_2.00
Drosophila melanogaster
SCACGHGHCA
TGDCDCGTGS
B1H
Zhu et al.(2011)
HLHm5_FlyReg_FBgn0002631
(Direct)
(Direct)
E(spl)m5-HLH
M05941_2.00
Drosophila melanogaster
RRCACGTGCCA
TGGCACGTGYY
B1H
Zhu et al.(2011)
HLHm5_SANGER_5_FBgn0002631
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
FBpp0084352
bHLH
19
73
LKVKKPLLERQRRARMNKCLDTLKTLVAEFQGDDAILRMDKAEMLEAALVFMRKQ
Links
Other
bHLH
family TFs
Other
Drosophila melanogaster
TFs
23 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy