E(spl)mdelta-HLH (Drosophila melanogaster)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 FBgn0002734 T038399_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables sequence-specific double-stranded DNA binding activity. Involved in several processes, including compound eye photoreceptor cell differentiation; regulation of neuroblast proliferation; and somatic muscle development. Predicted to be active in nucleus. Is expressed in several structures, including extended germ band embryo; eye disc; eye photoreceptor cell; germ layer; and presumptive embryonic/larval central nervous system. Orthologous to several human genes including HES6 (hes family bHLH transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
E(spl)mdelta-HLH
M03598_2.00		 Drosophila melanogaster
DTGGCACGTGCCAH
DTGGCACGTGCCAH		 SELEX
Nitta et al.(2015)
HLHmdelta_1		 (Direct) (Direct)
E(spl)mdelta-HLH
M05946_2.00		 Drosophila melanogaster
CRCGTGHCA
TGDCACGYG		 B1H
Zhu et al.(2011)
HLHmdelta_SANGER_10_FBgn0002734		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0084328 bHLH 16 73

Links

Other bHLH family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

12 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action