TF Information

E(spl)mgamma-HLH *(Drosophila melanogaster)* bHLH
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00010 (HLH)	IPR001092	FBgn0002735	T038400_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: Enables DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including neuronal stem cell population maintenance; positive regulation of neuroblast proliferation; and wing disc dorsal/ventral pattern formation. Located in nucleus. Is expressed in several structures, including extended germ band embryo; germ layer; larval optic anlage; presumptive embryonic/larval central nervous system; and thoracic segment. Used to study central nervous system cancer. Orthologous to human HES6 (hes family bHLH transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
E(spl)mgamma-HLH M03599_2.00	Drosophila melanogaster	DTGGCACGTGCCAH	DTGGCACGTGCCAH	SELEX Nitta et al.(2015) HLHmgamma_1	(Direct)	(Direct)
E(spl)mgamma-HLH M05947_2.00	Drosophila melanogaster	SCACGTGCCA	TGGCACGTGS	B1H Zhu et al.(2011) HLHmgamma_SANGER_10_FBgn0002735	(Direct)	(Direct)
E(spl)mgamma-HLH M05948_2.00	Drosophila melanogaster	CTTGACW	WGTCAAG	B1H Zhu et al.(2011) HLHmgamma_SANGER_5_2_FBgn0002735	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
E(spl)m3-HLH M03596_2.00	Drosophila melanogaster	DTGGCACGTGCCAH	DTGGCACGTGCCAH	SELEX Nitta et al.(2015) HLHm3_1	0.852	0.855
E(spl)m3-HLH M05939_2.00	Drosophila melanogaster	CACGTGVCA	TGBCACGTG	B1H Zhu et al.(2011) HLHm3_SANGER_5_FBgn0002609	0.852	0.855
For this family, TFs with SR scores > 0.838* will likely have a similar motif*