nau (Drosophila melanogaster)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 FBgn0002922 T038401_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in determination of muscle attachment site and larval somatic muscle development. Located in cytoplasm and nucleus. Is expressed in several structures, including muscle system; somatic mesoderm; somatic muscle primordium; and telson. Human ortholog(s) of this gene implicated in congenital structural myopathy. Orthologous to several human genes including MYOD1 (myogenic differentiation 1) and MYF5 (myogenic factor 5). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nau
M03600_2.00		 Drosophila melanogaster
DBAACAGCTGTYVH
DBRACAGCTGTTVH		 SELEX
Nitta et al.(2015)
nau_1		 (Direct) (Direct)
nau
M03601_2.00		 Drosophila melanogaster
NBRACAGCTGACRC
GYGTCAGCTGTYVN		 SELEX
Nitta et al.(2015)
nau_2		 (Direct) (Direct)
nau
M03602_2.00		 Drosophila melanogaster
RCGWCAGCTGWCGC
GCGWCAGCTGWCGY		 SELEX
Nitta et al.(2015)
nau_3		 (Direct) (Direct)
nau
M05949_2.00		 Drosophila melanogaster
CACCTGYY
RRCAGGTG		 B1H
Zhu et al.(2011)
nau_da_SANGER_5_FBgn0002922		 (Direct) (Direct)
nau
M05950_2.00		 Drosophila melanogaster
RACASCTGACGC
GCGTCAGSTGTY		 B1H
Zhu et al.(2011)
nau_SANGER_5_FBgn0002922		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
MYOD1
M04116_2.00 		Homo sapiens
BAACASSTGNYV
BRNCASSTGTTV		 SELEX
Yin et al.(2017)
MYOD1_eDBD_HT-SELEX_1 		0.866 0.885
MYOD1
M04117_2.00 		Homo sapiens
BRVCASMTGDCG
CGHCAKSTGBYV		 SELEX
Yin et al.(2017)
MYOD1_eDBD_HT-SELEX_2 		0.866 0.885
MYOD1
M04120_2.00 		Homo sapiens
NAACASSTGNYV
BRNCASSTGTTN		 SELEX
Yin et al.(2017)
MYOD1_FL_HT-SELEX_1 		0.866 0.885
MYOD1
M04121_2.00 		Homo sapiens
BRMCASCTGDCR
YGHCAGSTGKYV		 SELEX
Yin et al.(2017)
MYOD1_FL_HT-SELEX_2 		0.866 0.885
Myod1
M08060_2.00 		Mus musculus
NVNRRCAGSTGBN
NVCASCTGYYNBN		 ChIP-seq
Mathelier et al.(2014)
MA0499.1 		0.866 0.885
MYOD1
M08724_2.00 		Homo sapiens
NVNNRNRRCAGCTGN
NCAGCTGYYNYNNBN		 Misc
Kulakovskiy et al.(2013)
MYOD1_HUMAN.H11MO.0.A 		0.866 0.885
Myod1
M08745_2.00 		Mus musculus
NVNRRNRRCAGSTGB
VCASCTGYYNYYNBN		 Misc
Kulakovskiy et al.(2013)
MYOD1_MOUSE.H11MO.0.A 		0.866 0.885
MYOD1
M09838_2.00 		Homo sapiens
HRVCACCTGHBB
VVDCAGGTGBYD		 Transfac
Matys et al.(2006)
V$MYOD_01 		0.866 0.885
MYOD1
M09839_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$MYOD_Q6_02 		0.866 0.885
MYOD1
M09840_2.00 		Homo sapiens
NVCABCTGNY
RNCAGVTGBN		 Transfac
Matys et al.(2006)
V$MYOD_Q6 		0.866 0.885
MYOD1
M04118_2.00 		Homo sapiens
BAACANVTGTYV
BRACABNTGTTV		 SELEX
Yin et al.(2017)
MYOD1_eDBD_Methyl-HT-SELEX_1 		0.866 0.885
MYOD1
M04119_2.00 		Homo sapiens
BRRCASSTGDCR
YGHCASSTGYYV		 SELEX
Yin et al.(2017)
MYOD1_eDBD_Methyl-HT-SELEX_2 		0.866 0.885
MYOD1
M04122_2.00 		Homo sapiens
NAMCASSTGBYV
BRVCASSTGKTN		 SELEX
Yin et al.(2017)
MYOD1_FL_Methyl-HT-SELEX_1 		0.866 0.885
MYOD1
M04123_2.00 		Homo sapiens
BRMCASVTGNCR
YGNCABSTGKYV		 SELEX
Yin et al.(2017)
MYOD1_FL_Methyl-HT-SELEX_2 		0.866 0.885
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0083863 bHLH 162 213
FBpp0290660 bHLH 162 213

Links

Other bHLH family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

120 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action