| NCBI Gene Info:Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including adult walking behavior; determination of genital disc primordium; and nervous system development. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; embryonic/larval gut; extended germ band embryo; neurons; and presumptive embryonic/larval digestive system. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SIM1 (SIM bHLH transcription factor 1) and SIM2 (SIM bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022] |