dpn (Drosophila melanogaster)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 FBgn0010109 T038408_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including generation of neurons; regulation of gene expression; and sex determination, establishment of X:A ratio. Located in cytosol and nucleus. Is expressed in several structures, including ectoderm; embryonic/larval optic lobe; extended germ band embryo; neuroblasts; and presumptive embryonic/larval nervous system. Used to study brain cancer. Orthologous to several human genes including HES1 (hes family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
dpn
M03608_2.00		 Drosophila melanogaster
NGVCACGYGHNN
NNDCRCGTGBCN		 SELEX
Nitta et al.(2015)
dpn_1		 (Direct) (Direct)
dpn
M05959_2.00		 Drosophila melanogaster
GRCRCGTGSCR
YGSCACGYGYC		 B1H
Zhu et al.(2011)
dpn_SANGER_10_FBgn0010109		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0087879 bHLH 41 98

Links

Other bHLH family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

19 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action