HLH4C (Drosophila melanogaster)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 FBgn0011277 T038411_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
HLH4C
M03609_2.00
Drosophila melanogaster
DDNCRCAGCTGYGNHH

DDNCRCAGCTGYGNHH
SELEX
Nitta et al.(2015)
HLH4C_1
(Direct) (Direct)
HLH4C
M03610_2.00
Drosophila melanogaster
DRSMYCAGCTGVKSYH

DRSMBCAGCTGRKSYH
SELEX
Nitta et al.(2015)
HLH4C_2
(Direct) (Direct)
HLH4C
M03611_2.00
Drosophila melanogaster
NRBMYCAGCTGYGNHH

DDNCRCAGCTGRKVYN
SELEX
Nitta et al.(2015)
HLH4C_3
(Direct) (Direct)
HLH4C
M05963_2.00
Drosophila melanogaster
CACCTGMDCC

GGHKCAGGTG
B1H
Zhu et al.(2011)
HLH4C_da_SANGER_5_3_FBgn0011277
(Direct) (Direct)
HLH4C
M05964_2.00
Drosophila melanogaster
MCAYCTGMGMMM

KKKCKCAGRTGK
B1H
Zhu et al.(2011)
HLH4C_da_SANGER_5_4_FBgn0011277
(Direct) (Direct)
HLH4C
M05965_2.00
Drosophila melanogaster
VNHHVCACCTGMBNC

GNVKCAGGTGBDDNB
B1H
Zhu et al.(2011)
HLH4C_da_SANGER_5_FBgn0011277
(Direct) (Direct)
HLH4C
M05966_2.00
Drosophila melanogaster
RGSMYCAGCTGCGYY

RRCGCAGCTGRKSCY
B1H
Zhu et al.(2011)
HLH4C_SANGER_5_FBgn0011277
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
NHLH1
M02796_2.00
Homo sapiens
CGCAGCTGCB

VGCAGCTGCG
SELEX
Jolma et al.(2013)
NHLH1_1
0.891 0.923
NHLH1
M02797_2.00
Homo sapiens
VGCAGCTGCK

MGCAGCTGCB
SELEX
Jolma et al.(2013)
NHLH1_2
0.891 0.923
NHLH1
M04162_2.00
Homo sapiens
NDGNMKCAGCTGCGYCMH

DKGRCGCAGCTGMKNCHN
SELEX
Yin et al.(2017)
NHLH1_eDBD_HT-SELEX
0.891 0.923
NHLH1
M04164_2.00
Homo sapiens
NDGNMKCAGCTGCGYCMH

DKGRCGCAGCTGMKNCHN
SELEX
Yin et al.(2017)
NHLH1_FL_HT-SELEX
0.891 0.923
Nhlh1
M08773_2.00
Mus musculus
BKGGNMNCAGCTGCGBCCYY

RRGGVCGCAGCTGNKNCCMV
Misc
Kulakovskiy et al.(2013)
HEN1_MOUSE.H11MO.0.C
0.891 0.923
NHLH1
M09875_2.00
Homo sapiens
NNDGGNMVCAGCTGVGNCCNNN

NNNGGNCBCAGCTGBKNCCHNN
Transfac
Matys et al.(2006)
V$HEN1_01
0.891 0.923
NHLH1
M09876_2.00
Homo sapiens
NDRGGVMGCAGCTGMKNCCHHN

NDDGGNMKCAGCTGCKBCCYHN
Transfac
Matys et al.(2006)
V$HEN1_02
0.891 0.923
NHLH1
M04163_2.00
Homo sapiens
NRGBMKCAGCTGCGYCCH

DGGRCGCAGCTGMKVCYN
SELEX
Yin et al.(2017)
NHLH1_eDBD_Methyl-HT-SELEX
0.891 0.923
NHLH1
M04165_2.00
Homo sapiens
DGGNMBCAGCTGCGYCCH

DGGRCGCAGCTGVKNCCH
SELEX
Yin et al.(2017)
NHLH1_FL_Methyl-HT-SELEX
0.891 0.923
Nhlh2
M00756_2.00
Mus musculus
NKCAGCTGHN

NDCAGCTGMN
PBM
Weirauch et al.(2013)
pTH3037
0.891 0.904
NHLH2
M04177_2.00
Homo sapiens
DDGNMGCAGCTGCGYCMH

DKGRCGCAGCTGCKNCHH
SELEX
Yin et al.(2017)
NHLH2_FL_HT-SELEX
0.891 0.904
NHLH2
M09878_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HEN2_Q2
0.891 0.904
NHLH2
M04178_2.00
Homo sapiens
DGGNMBCAGCTGCGYCCH

DGGRCGCAGCTGVKNCCH
SELEX
Yin et al.(2017)
NHLH2_FL_Methyl-HT-SELEX
0.891 0.904
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0070659 bHLH 109 161
FBpp0303590 bHLH 109 161

Links

Other bHLH family TFs
Other Drosophila melanogaster TFs

168 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
GH17630 Drosophila grimshawi FBgn0125100 I 0.914
GI16068 Drosophila mojavensis FBgn0138817 I 0.914
GA15893 Drosophila pseudoobscura FBgn0075909 I 0.914
GG18528 Drosophila erecta FBgn0110741 I 0.914
GF20856 Drosophila ananassae FBgn0097862 I 0.914
GL14555 Drosophila persimilis FBgn0152160 I 0.914
GM12676 Drosophila sechellia FBgn0167612 I 0.914
GE16844 Drosophila yakuba FBgn0234336 I 0.914
GK16457 Drosophila willistoni FBgn0218459 I 0.914
GJ15714 Drosophila virilis FBgn0202902 I 0.914
GD16284 Drosophila simulans FBgn0187911 I 0.914
LCUP012274 Lucilia cuprina LCUP012274 I 0.914
MDOA013398 Musca domestica MDOA013398 I 0.914
MDOA007431 Musca domestica MDOA007431 I 0.914
CapteG162858 Capitella teleta CapteG162858 I 0.911
ADAC006978 Anopheles darlingi ADAC006978 I 0.911
ACYPI007008 Acyrthosiphon pisum ACYPI007008 I 0.911
AGAP004907 Anopheles gambiae AGAP004907 I 0.911
LLOJ002704 Lutzomyia longipalpis LLOJ002704 I 0.911
BGLB013717 Biomphalaria glabrata BGLB013717 I 0.911
AAEL004428 Aedes aegypti AAEL004428 I 0.911
Gfo_R014815 Geospiza fortis Gfo_R014815 I 0.911
nhlh2 Takifugu rubripes ENSTRUG00000003636 I 0.911
nhlh2 Tetraodon nigroviridis ENSTNIG00000010331 I 0.911
YQE_11502 Dendroctonus ponderosae YQE_11502 I 0.911
YQE_04623 Dendroctonus ponderosae YQE_04623 I 0.911
ENSPFOG00000020651 Poecilia formosa ENSPFOG00000020651 I 0.911
PPAI007861 Phlebotomus papatasi PPAI007861 I 0.911
LotgiG133561 Lottia gigantea LotgiG133561 I 0.911
L798_00559 Zootermopsis nevadensis L798_00559 I 0.911
ISCW014797 Ixodes scapularis ISCW014797 I 0.911
PHUM229200 Pediculus humanus PHUM229200 I 0.911
RPRC001173 Rhodnius prolixus RPRC001173 I 0.911
TC007725 Tribolium castaneum TC007725 I 0.911
YQE_00442 Dendroctonus ponderosae YQE_00442 I 0.911
SPU_009231 Strongylocentrotus purpuratus SPU_009231 I 0.911
SMAR007908 Strigamia maritima SMAR007908 I 0.911
ENSONIG00000021015 Oreochromis niloticus ENSONIG00000021015 I 0.911
AQUA014034 Anopheles quadriannulatus AQUA014034 I 0.911
ASTEI10641 Anopheles stephensi ASTEI10641 I 0.911
ACUA026679 Anopheles culicifacies ACUA026679 I 0.911
ADIR001683 Anopheles dirus ADIR001683 I 0.911
nhlh2 Danio rerio ENSDARG00000025495 I 0.911
ACUA009159 Anopheles culicifacies ACUA009159 I 0.911
ACOM036372 Anopheles coluzzii ACOM036372 I 0.911
AEPI011485 Anopheles epiroticus AEPI011485 I 0.911
AFAF009162 Anopheles farauti AFAF009162 I 0.911
AMEM004741 Anopheles merus AMEM004741 I 0.911
AMIN011405 Anopheles minimus AMIN011405 I 0.911
AMEC009920 Anopheles melas AMEC009920 I 0.911
AMAM022568 Anopheles maculatus AMAM022568 I 0.911
AFUN005050 Anopheles funestus AFUN005050 I 0.911
ENSLOCG00000017787 Lepisosteus oculatus ENSLOCG00000017787 I 0.911
AATE010880 Anopheles atroparvus AATE010880 I 0.911
Ocbimv22001940m.g Octopus bimaculoides Ocbimv22001940m.g I 0.911
HHAL001761-PA Halyomorpha halys HHAL001761-PA I 0.911
ENSGMOG00000020309 Gadus morhua ENSGMOG00000020309 I 0.911
CLEC002464 Cimex lectularius CLEC002464 I 0.911
Sakowv30004475m.g Saccoglossus kowalevskii Sakowv30004475m.g I 0.911
AARA003512 Anopheles arabiensis AARA003512 I 0.911
LDEC000946 Leptinotarsa decemlineata LDEC000946 I 0.911
ENSAMXG00000026006 Astyanax mexicanus ENSAMXG00000026006 I 0.911
AALB004585 Anopheles albimanus AALB004585 I 0.911
ENSXMAG00000020348 Xiphophorus maculatus ENSXMAG00000020348 I 0.911
ASIS019843 Anopheles sinensis ASIS019843 I 0.911
nhlh2 Gasterosteus aculeatus ENSGACG00000014053 I 0.911
GB53325 Apis mellifera GB53325 I 0.891
HelroG138545 Helobdella robusta HelroG138545 I 0.891
GB49291 Apis mellifera GB49291 I 0.891
Hsal_11874--XP_001122281.1_APIME Harpegnathos saltator Hsal_11874--XP_001122281.1_APIME I 0.891
Ogr08231 Ophisaurus gracilis Ogr08231 I 0.891
ENSP00000405915 Macaca fascicularis ENSP00000405915 I 0.891
ENSP00000358519-D1 Bos grunniens ENSP00000358519-D1 I 0.891
Pvit_07565 Pogona vitticeps Pvit_07565 I 0.891
nhlh1.S Xenopus laevis XB-GENE-6252028 I 0.891
nhlh1.L Xenopus laevis XB-GENE-989792 I 0.891
nhlh1 Xenopus tropicalis XB-GENE-989790 I 0.891
ENSP00000302189 Macaca fascicularis ENSP00000302189 I 0.891
Cmyd_10014342 Chelonia mydas Cmyd_10014342 I 0.891
Aan_R014318 Calypte anna Aan_R014318 I 0.891
NV10733 Nasonia vitripennis NV10733 I 0.891
MCINX015834 Melitaea cinxia MCINX015834 I 0.891
Alligator_sinensis_CCG011163.1 Alligator sinensis Alligator_sinensis_CCG011163.1 I 0.891
Alligator_sinensis_CCG018876.1 Alligator sinensis Alligator_sinensis_CCG018876.1 I 0.891
Cmyd_10010324 Chelonia mydas Cmyd_10010324 I 0.891
Cflo_11933--XP_001122281.1_APIME Camponotus floridanus Cflo_11933--XP_001122281.1_APIME I 0.891
KGM_06532 Danaus plexippus KGM_06532 I 0.891
ENSTSYG00000000582 Tarsius syrichta ENSTSYG00000000582 I 0.891
NHLH2 Gorilla gorilla ENSGGOG00000008283 I 0.891
NHLH1 Gorilla gorilla ENSGGOG00000015736 I 0.891
ENSLACG00000011363 Latimeria chalumnae ENSLACG00000011363 I 0.891
NHLH1 Gallus gallus ENSGALG00000025817 I 0.891
NHLH2 Homo sapiens ENSG00000177551 D 0.891
ENSFALG00000006103 Ficedula albicollis ENSFALG00000006103 I 0.891
ENSFCAG00000028313 Felis catus ENSFCAG00000028313 I 0.891
NHLH1 Homo sapiens ENSG00000171786 D 0.891
NHLH2 Loxodonta africana ENSLAFG00000007456 I 0.891
NHLH1 Loxodonta africana ENSLAFG00000011163 I 0.891
NHLH2 Myotis lucifugus ENSMLUG00000015989 I 0.891
NHLH2 Tursiops truncatus ENSTTRG00000003112 I 0.891
NHLH1 Macaca mulatta ENSMMUG00000021865 I 0.891
NHLH1 Microcebus murinus ENSMICG00000012700 I 0.891
ENSMICG00000002851 Microcebus murinus ENSMICG00000002851 I 0.891
ENSMEUG00000003022 Macropus eugenii ENSMEUG00000003022 I 0.891
ENSMGAG00000016096 Meleagris gallopavo ENSMGAG00000016096 I 0.891
NHLH1 Echinops telfairi ENSETEG00000009677 I 0.891
NHLH1 Equus caballus ENSECAG00000004612 I 0.891
NHLH2 Bos taurus ENSBTAG00000015067 I 0.891
NHLH1 Bos taurus ENSBTAG00000020027 I 0.891
NHLH2 Canis familiaris ENSCAFG00000009767 I 0.891
ENSACAG00000010649 Anolis carolinensis ENSACAG00000010649 I 0.891
NHLH2 Anolis carolinensis ENSACAG00000003304 I 0.891
ACEP10202 Atta cephalotes ACEP10202 I 0.891
BGIBMGA008476 Bombyx mori BGIBMGA008476 I 0.891
DAPPUDRAFT_66944 Daphnia pulex DAPPUDRAFT_66944 I 0.891
NHLH1 Canis familiaris ENSCAFG00000023513 I 0.891
NHLH1 Callithrix jacchus ENSCJAG00000005775 I 0.891
ENSCSAG00000000172 Chlorocebus sabaeus ENSCSAG00000000172 I 0.891
NHLH2 Dasypus novemcinctus ENSDNOG00000008961 I 0.891
NHLH1 Dasypus novemcinctus ENSDNOG00000038600 I 0.891
ENSCSAG00000000087 Chlorocebus sabaeus ENSCSAG00000000087 I 0.891
NHLH2 Cavia porcellus ENSCPOG00000026593 I 0.891
NHLH2 Callithrix jacchus ENSCJAG00000012807 I 0.891
NHLH1 Cavia porcellus ENSCPOG00000021596 I 0.891
NHLH2 Monodelphis domestica ENSMODG00000023228 I 0.891
ENSMMUG00000008971 Macaca mulatta ENSMMUG00000008971 I 0.891
NHLH1 Pteropus vampyrus ENSPVAG00000007987 I 0.891
NHLH2 Pteropus vampyrus ENSPVAG00000012688 I 0.891
Nhlh1 Rattus norvegicus ENSRNOG00000005166 I 0.891
NHLH1 Pan troglodytes ENSPTRG00000001551 I 0.891
NHLH2 Pan troglodytes ENSPTRG00000001149 I 0.891
ENSPPYG00000000632 Pongo abelii ENSPPYG00000000632 I 0.891
NHLH1 Monodelphis domestica ENSMODG00000024591 I 0.891
Nhlh2 Rattus norvegicus ENSRNOG00000054375 I 0.891
ENSSHAG00000006613 Sarcophilus harrisii ENSSHAG00000006613 I 0.891
ENSSTOG00000027988 Ictidomys tridecemlineatus ENSSTOG00000027988 I 0.891
NHLH1 Taeniopygia guttata ENSTGUG00000013389 I 0.891
NHLH1 Tursiops truncatus ENSTTRG00000001840 I 0.891
ENSSTOG00000019698 Ictidomys tridecemlineatus ENSSTOG00000019698 I 0.891
NHLH2 Sus scrofa ENSSSCG00000006744 I 0.891
ENSSHAG00000015472 Sarcophilus harrisii ENSSHAG00000015472 I 0.891
NHLH1 Sus scrofa ENSSSCG00000006384 I 0.891
NHLH1 Procavia capensis ENSPCAG00000009061 I 0.891
ENSPPYG00000000988 Pongo abelii ENSPPYG00000000988 I 0.891
ENSNLEG00000013637 Nomascus leucogenys ENSNLEG00000013637 I 0.891
NHLH2 Oryctolagus cuniculus ENSOCUG00000015744 I 0.891
NHLH1 Otolemur garnettii ENSOGAG00000010592 I 0.891
Nhlh1 Mus musculus ENSMUSG00000051251 D 0.891
Nhlh2 Mus musculus ENSMUSG00000048540 D 0.891
ENSMPUG00000019387 Mustela putorius furo ENSMPUG00000019387 I 0.891
ENSMPUG00000019473 Mustela putorius furo ENSMPUG00000019473 I 0.891
NHLH2 Otolemur garnettii ENSOGAG00000034540 I 0.891
NHLH2 Ornithorhynchus anatinus ENSOANG00000009820 I 0.891
ENSPANG00000011970 Papio anubis ENSPANG00000011970 I 0.891
ENSPANG00000001481 Papio anubis ENSPANG00000001481 I 0.891
NHLH2 Ochotona princeps ENSOPRG00000006661 I 0.891
HelroG94416 Helobdella robusta HelroG94416 I 0.887
Cmyd_10001044 Chelonia mydas Cmyd_10001044 I 0.879
MESCA010279 Megaselia scalaris MESCA010279 I 0.870
CGI_10002829 Crassostrea gigas CGI_10002829 I 0.867
nRc.2.0.1.g35713 Romanomermis culicivorax nRc.2.0.1.g35713 I 0.867
ENSAMEG00000010851 Ailuropoda melanoleuca ENSAMEG00000010851 I 0.867
HelroG153470 Helobdella robusta HelroG153470 I 0.867
BXY_0231500 Bursaphelenchus xylophilus BXY_0231500 I 0.861
Brh_R005283 Buceros rhinoceros Brh_R005283 I 0.858
SMU15030866 Schmidtea mediterranea SMU15030866 I 0.854
ENSONIG00000020673 Oreochromis niloticus ENSONIG00000020673 I 0.843