HLH4C (Drosophila melanogaster)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 FBgn0011277 T038411_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in extended germ band embryo; larval ventral nerve cord; neurons; and presumptive embryonic/larval central nervous system. Orthologous to several human genes including NHLH1 (nescient helix-loop-helix 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HLH4C
M03609_2.00		 Drosophila melanogaster
DDNCRCAGCTGYGNHH
DDNCRCAGCTGYGNHH		 SELEX
Nitta et al.(2015)
HLH4C_1		 (Direct) (Direct)
HLH4C
M03610_2.00		 Drosophila melanogaster
DRSMYCAGCTGVKSYH
DRSMBCAGCTGRKSYH		 SELEX
Nitta et al.(2015)
HLH4C_2		 (Direct) (Direct)
HLH4C
M03611_2.00		 Drosophila melanogaster
NRBMYCAGCTGYGNHH
DDNCRCAGCTGRKVYN		 SELEX
Nitta et al.(2015)
HLH4C_3		 (Direct) (Direct)
HLH4C
M05963_2.00		 Drosophila melanogaster
CACCTGMDCC
GGHKCAGGTG		 B1H
Zhu et al.(2011)
HLH4C_da_SANGER_5_3_FBgn0011277		 (Direct) (Direct)
HLH4C
M05964_2.00		 Drosophila melanogaster
MCAYCTGMGMMM
KKKCKCAGRTGK		 B1H
Zhu et al.(2011)
HLH4C_da_SANGER_5_4_FBgn0011277		 (Direct) (Direct)
HLH4C
M05965_2.00		 Drosophila melanogaster
VNHHVCACCTGMBNC
GNVKCAGGTGBDDNB		 B1H
Zhu et al.(2011)
HLH4C_da_SANGER_5_FBgn0011277		 (Direct) (Direct)
HLH4C
M05966_2.00		 Drosophila melanogaster
RGSMYCAGCTGCGYY
RRCGCAGCTGRKSCY		 B1H
Zhu et al.(2011)
HLH4C_SANGER_5_FBgn0011277		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
NHLH1
M02796_2.00 		Homo sapiens
CGCAGCTGCB
VGCAGCTGCG		 SELEX
Jolma et al.(2013)
NHLH1_1 		0.891 0.923
NHLH1
M02797_2.00 		Homo sapiens
VGCAGCTGCK
MGCAGCTGCB		 SELEX
Jolma et al.(2013)
NHLH1_2 		0.891 0.923
NHLH1
M04162_2.00 		Homo sapiens
NDGNMKCAGCTGCGYCMH
DKGRCGCAGCTGMKNCHN		 SELEX
Yin et al.(2017)
NHLH1_eDBD_HT-SELEX 		0.891 0.923
NHLH1
M04164_2.00 		Homo sapiens
NDGNMKCAGCTGCGYCMH
DKGRCGCAGCTGMKNCHN		 SELEX
Yin et al.(2017)
NHLH1_FL_HT-SELEX 		0.891 0.923
Nhlh1
M08773_2.00 		Mus musculus
BKGGNMNCAGCTGCGBCCYY
RRGGVCGCAGCTGNKNCCMV		 Misc
Kulakovskiy et al.(2013)
HEN1_MOUSE.H11MO.0.C 		0.891 0.923
NHLH1
M09875_2.00 		Homo sapiens
NNDGGNMVCAGCTGVGNCCNNN
NNNGGNCBCAGCTGBKNCCHNN		 Transfac
Matys et al.(2006)
V$HEN1_01 		0.891 0.923
NHLH1
M09876_2.00 		Homo sapiens
NDRGGVMGCAGCTGMKNCCHHN
NDDGGNMKCAGCTGCKBCCYHN		 Transfac
Matys et al.(2006)
V$HEN1_02 		0.891 0.923
NHLH1
M04163_2.00 		Homo sapiens
NRGBMKCAGCTGCGYCCH
DGGRCGCAGCTGMKVCYN		 SELEX
Yin et al.(2017)
NHLH1_eDBD_Methyl-HT-SELEX 		0.891 0.923
NHLH1
M04165_2.00 		Homo sapiens
DGGNMBCAGCTGCGYCCH
DGGRCGCAGCTGVKNCCH		 SELEX
Yin et al.(2017)
NHLH1_FL_Methyl-HT-SELEX 		0.891 0.923
Nhlh2
M00756_2.00 		Mus musculus
NKCAGCTGHN
NDCAGCTGMN		 PBM
Weirauch et al.(2013)
pTH3037 		0.891 0.904
NHLH2
M04177_2.00 		Homo sapiens
DDGNMGCAGCTGCGYCMH
DKGRCGCAGCTGCKNCHH		 SELEX
Yin et al.(2017)
NHLH2_FL_HT-SELEX 		0.891 0.904
NHLH2
M09878_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HEN2_Q2 		0.891 0.904
NHLH2
M04178_2.00 		Homo sapiens
DGGNMBCAGCTGCGYCCH
DGGRCGCAGCTGVKNCCH		 SELEX
Yin et al.(2017)
NHLH2_FL_Methyl-HT-SELEX 		0.891 0.904
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0070659 bHLH 109 161
FBpp0303590 bHLH 109 161

Links

Other bHLH family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

168 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action