CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Max
(
Drosophila melanogaster
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
FBgn0017578
T038420_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity and protein heterodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including anterior endoderm; embryonic Malpighian tubule; embryonic/larval midgut; extended germ band embryo; and visceral muscle primordium. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Orthologous to human MAX (MYC associated factor X). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Max
M03612_2.00
Drosophila melanogaster
VRAMCACGTGBTYB
VRAVCACGTGKTYB
SELEX
Nitta et al.(2015)
Max_1
(Direct)
(Direct)
Max
M05969_2.00
Drosophila melanogaster
HCCACGTGBY
RVCACGTGGD
B1H
Zhu et al.(2011)
dm_Max_SANGER_10_FBgn0017578
(Direct)
(Direct)
Max
M05970_2.00
Drosophila melanogaster
CCACGTG
CACGTGG
B1H
Zhu et al.(2011)
Max_Mnt_SANGER_5_FBgn0017578
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
FBpp0074785
bHLH
40
91
KRAHHNALERRRRDHIKESFTNLREAVPTLKGEKASRAQILKKTTECIQTMR
FBpp0301959
bHLH
40
91
KRAHHNALERRRRDHIKESFTNLREAVPTLKGEKASRAQILKKTTECIQTMR
FBpp0311541
bHLH
40
91
KRAHHNALERRRRDHIKESFTNLREAVPTLKGEKASRAQILKKTTECIQTMR
Links
Other
bHLH
family TFs
Other
Drosophila melanogaster
TFs
19 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy