Max (Drosophila melanogaster)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 FBgn0017578 T038420_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity and protein heterodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including anterior endoderm; embryonic Malpighian tubule; embryonic/larval midgut; extended germ band embryo; and visceral muscle primordium. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Orthologous to human MAX (MYC associated factor X). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Max
M03612_2.00		 Drosophila melanogaster
VRAMCACGTGBTYB
VRAVCACGTGKTYB		 SELEX
Nitta et al.(2015)
Max_1		 (Direct) (Direct)
Max
M05969_2.00		 Drosophila melanogaster
HCCACGTGBY
RVCACGTGGD		 B1H
Zhu et al.(2011)
dm_Max_SANGER_10_FBgn0017578		 (Direct) (Direct)
Max
M05970_2.00		 Drosophila melanogaster
CCACGTG
CACGTGG		 B1H
Zhu et al.(2011)
Max_Mnt_SANGER_5_FBgn0017578		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0074785 bHLH 40 91
FBpp0301959 bHLH 40 91
FBpp0311541 bHLH 40 91

Links

Other bHLH family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

19 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action