Clk (Drosophila melanogaster)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 FBgn0023076 T038425_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA binding activity; chromatin binding activity; and protein heterodimerization activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including circadian regulation of heart rate; locomotor rhythm; and regulation of gene expression. Part of CLOCK-BMAL transcription complex. Is expressed in several structures, including adult fat body; adult oenocyte; head; intrinsic neurons; and pacemaker neurons. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to several human genes including CLOCK (clock circadian regulator) and NPAS2 (neuronal PAS domain protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Clk
M05972_2.00		 Drosophila melanogaster
MCACGTGV
BCACGTGK		 B1H
Zhu et al.(2011)
Clk_cyc_SANGER_5_FBgn0023076		 (Direct) (Direct)
Clk
M05973_2.00		 Drosophila melanogaster
CACGTGSY
RSCACGTG		 B1H
Zhu et al.(2011)
gce_Clk_SANGER_5_FBgn0023076		 (Direct) (Direct)
Clk
M05974_2.00		 Drosophila melanogaster
CACGTGKM
KACACGTG		 B1H
Zhu et al.(2011)
Met_Clk_SANGER_5_FBgn0023076		 (Direct) (Direct)
Clk
M05975_2.00		 Drosophila melanogaster
SACACGTGY
RCACGTGTS		 B1H
Zhu et al.(2011)
tai_Clk_SANGER_5_FBgn0023076		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0076500 bHLH 12 61
FBpp0099478 bHLH 16 65

Links

Other bHLH family TFs
Other Drosophila melanogaster TFs

31 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
GL17825 Drosophila persimilis FBgn0155428 I 0.914
GM24989 Drosophila sechellia FBgn0179850 I 0.914
GD13034 Drosophila simulans FBgn0184756 I 0.914
GE20390 Drosophila yakuba FBgn0237706 I 0.914
GI12195 Drosophila mojavensis FBgn0134952 I 0.914
GK10694 Drosophila willistoni FBgn0212707 I 0.914
GG14938 Drosophila erecta FBgn0107192 I 0.914
GA20318 Drosophila pseudoobscura FBgn0080313 I 0.914
MCINX000525 Melitaea cinxia MCINX000525 I 0.892
KGM_10878 Danaus plexippus KGM_10878 I 0.892
LCUP014936 Lucilia cuprina LCUP014936 I 0.890
GJ11427 Drosophila virilis FBgn0198685 I 0.890
GH16514 Drosophila grimshawi FBgn0123985 I 0.884
GF24152 Drosophila ananassae FBgn0101146 I 0.884
RPRC002110 Rhodnius prolixus RPRC002110 I 0.880
PHUM426300 Pediculus humanus PHUM426300 I 0.880
CLEC000211 Cimex lectularius CLEC000211 I 0.880
HHAL003628-PA Halyomorpha halys HHAL003628-PA I 0.880
DAPPUDRAFT_346996 Daphnia pulex DAPPUDRAFT_346996 I 0.880
YQE_03736 Dendroctonus ponderosae YQE_03736 I 0.868
TC000088 Tribolium castaneum TC000088 I 0.868
NV19013 Nasonia vitripennis NV19013 I 0.865
Cflo_02744--XP_394233.3_APIME Camponotus floridanus Cflo_02744--XP_394233.3_APIME I 0.864
LLOJ006614 Lutzomyia longipalpis LLOJ006614 I 0.861
GB48028 Apis mellifera GB48028 I 0.861
ACEP20954 Atta cephalotes ACEP20954 I 0.861
Hsal_05831--XP_394233.3_APIME Harpegnathos saltator Hsal_05831--XP_394233.3_APIME I 0.861
PPAI002844 Phlebotomus papatasi PPAI002844 I 0.861
ISCW007040 Ixodes scapularis ISCW007040 I 0.856
HMEL008784 Heliconius melpomene HMEL008784 I 0.850