Mio (Drosophila melanogaster)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 FBgn0032940 T038443_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Predicted to contribute to DNA binding activity. Involved in glucose homeostasis; response to sucrose; and triglyceride homeostasis. Located in cytosol. Is expressed in several structures, including blastoderm embryo; brain; embryonic/larval fat body; extended germ band embryo; and germ layer. Orthologous to human MLXIP (MLX interacting protein) and MLXIPL (MLX interacting protein like). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Mio
M05989_2.00		 Drosophila melanogaster
DTCACGTG
CACGTGAH		 B1H
Zhu et al.(2011)
Mio_bigmax_SANGER_5_FBgn0032940		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0081052 bHLH 912 966
FBpp0081052 bHLH 970 1009
FBpp0081053 bHLH 912 966
FBpp0081053 bHLH 970 1009
FBpp0081055 bHLH 718 772
FBpp0081055 bHLH 775 815
FBpp0290672 bHLH 912 966
FBpp0290672 bHLH 970 1009
FBpp0290673 bHLH 912 966
FBpp0290673 bHLH 970 1009
FBpp0290674 bHLH 912 966
FBpp0290674 bHLH 970 1009
FBpp0290675 bHLH 912 966
FBpp0290675 bHLH 970 1009
FBpp0290676 bHLH 912 966
FBpp0290676 bHLH 970 1009
FBpp0290677 bHLH 912 966
FBpp0290677 bHLH 970 1009
FBpp0290678 bHLH 912 966
FBpp0290678 bHLH 970 1009
FBpp0290679 bHLH 912 966
FBpp0290679 bHLH 970 1009

Links

Other bHLH family TFs
Other Drosophila melanogaster TFs

8 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
GM23262 Drosophila sechellia FBgn0178129 I 0.893
GE12990 Drosophila yakuba FBgn0230699 I 0.893
GL26357 Drosophila persimilis FBgn0163939 I 0.893
GG21509 Drosophila erecta FBgn0113688 I 0.893
GA14905 Drosophila pseudoobscura FBgn0074931 I 0.866
GF15566 Drosophila ananassae FBgn0092591 I 0.857
GH13021 Drosophila grimshawi FBgn0120499 I 0.849