CIS-BP Database: Catalog of Inferred Sequence Binding Preferences

TF Information

cwo *(Drosophila melanogaster)* bHLH
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00010 (HLH)	IPR001092	FBgn0259938	T039049_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: Enables DNA-binding transcription factor activity. Involved in dendrite morphogenesis; regulation of circadian rhythm; and regulation of gene expression. Located in nucleus. Is expressed in several structures, including adult fat body; extended germ band embryo; gut section; head; and pacemaker neurons. Orthologous to human HELT (helt bHLH transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
cwo M03623_2.00	Drosophila melanogaster	DRRTCACGTGAYYH	DRRTCACGTGAYYH	SELEX Nitta et al.(2015) cwo_1	(Direct)	(Direct)
cwo M03624_2.00	Drosophila melanogaster	RKCACGTGMY	RKCACGTGMY	SELEX Nitta et al.(2015) cwo_2	(Direct)	(Direct)
cwo M03625_2.00	Drosophila melanogaster	NDCACGTGHNNNDCACGTGHN	NDCACGTGHNNNDCACGTGHN	SELEX Nitta et al.(2015) cwo_3	(Direct)	(Direct)
cwo M06001_2.00	Drosophila melanogaster	RTCACGTGACCR	YGGTCACGTGAY	B1H Zhu et al.(2011) cwo_SANGER_5_FBgn0259938	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
For this family, TFs with SR scores > 0.838* will likely have a similar motif*

DNA Binding Domains

Protein ID	Domain	From	To	Sequence
FBpp0081723	bHLH	65	118	LSHRIIEKRRRDRMNSCLADLSRLIPPQYQRKGRGRIEKTEIIEMAIRHLKHLQ
FBpp0293681	bHLH	1	41	MNSCLADLSRLIPPQYQRKGRGRIEKTEIIEMAIRHLKHLQ
FBpp0293682	bHLH	1	41	MNSCLADLSRLIPPQYQRKGRGRIEKTEIIEMAIRHLKHLQ

Links
Other bHLH family TFs
Other *Drosophila melanogaster* TFs