| NCBI Gene Info:Enables DNA binding activity; DNA-binding transcription factor activity; and ubiquitin-specific protease binding activity. Involved in several processes, including DNA endoreduplication; cell competition in a multicellular organism; and positive regulation of transcription, DNA-templated. Located in nucleus. Part of protein-containing complex. Colocalizes with histone locus body. Is expressed in several structures, including extended germ band embryo; female-specific anatomical entity; imaginal disc; presumptive embryonic/larval digestive system; and stage 5 embryo. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including Feingold syndrome; carcinoma (multiple); demyelinating disease; hematologic cancer (multiple); and prostate cancer (multiple). Orthologous to several human genes including MYC (MYC proto-oncogene, bHLH transcription factor). [provided by Alliance of Genome Resources, Apr 2022] |