NCBI Gene Info:Enables sequence-specific DNA binding activity. Involved in several processes, including compound eye morphogenesis; lysosome organization; and positive regulation of autophagosome maturation. Predicted to be active in nucleus. Is expressed in several structures, including anterior ectoderm; anterior ectoderm anlage; extended germ band embryo; labral segment; and presumptive embryonic/larval system. Used to study lysosomal storage disease. Human ortholog(s) of this gene implicated in Tietz syndrome; Tietze's syndrome; Waardenburg's syndrome (multiple); familial melanoma; and renal cell carcinoma. Orthologous to several human genes including MITF (melanocyte inducing transcription factor) and TFEB (transcription factor EB). [provided by Alliance of Genome Resources, Apr 2022] |