Mitf (Drosophila melanogaster)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 FBgn0263112 T039056_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables sequence-specific DNA binding activity. Involved in several processes, including compound eye morphogenesis; lysosome organization; and positive regulation of autophagosome maturation. Predicted to be active in nucleus. Is expressed in several structures, including anterior ectoderm; anterior ectoderm anlage; extended germ band embryo; labral segment; and presumptive embryonic/larval system. Used to study lysosomal storage disease. Human ortholog(s) of this gene implicated in Tietz syndrome; Tietze's syndrome; Waardenburg's syndrome (multiple); familial melanoma; and renal cell carcinoma. Orthologous to several human genes including MITF (melanocyte inducing transcription factor) and TFEB (transcription factor EB). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Mitf
M06003_2.00		 Drosophila melanogaster
TCACGTG
CACGTGA		 B1H
Zhu et al.(2011)
Mitf_SANGER_5_FBgn0263112		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0298327 bHLH 401 460
FBpp0298328 bHLH 401 460
FBpp0298329 bHLH 508 567
FBpp0298330 bHLH 375 434

Links

Other bHLH family TFs
Other Drosophila melanogaster TFs

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14 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action