| NCBI Gene Info:Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; bHLH transcription factor binding activity; and protein dimerization activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including generation of neurons; nematode male tail tip morphogenesis; and positive regulation of macromolecule metabolic process. Acts upstream of or within with a positive effect on determination of adult lifespan. Acts upstream of or within with a negative effect on reproductive senescence. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including gonad. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; Pitt-Hopkins syndrome; agammaglobulinemia; colorectal cancer; and craniosynostosis. Orthologous to human TCF12 (transcription factor 12); TCF3 (transcription factor 3); and TCF4 (transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022] |