| NCBI Gene Info:Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in mesodermal cell fate specification; positive regulation of transcription by RNA polymerase II; and vulval cell fate specification. Predicted to be located in nucleus. Is expressed in several structures, including M cell; M.dlpa male; M.drpa male; anal depressor muscle; and body muscle cell. Used to study Saethre-Chotzen syndrome. Human ortholog(s) of this gene implicated in Barber-Say syndrome; Sweeney-Cox syndrome; ablepharon macrostomia syndrome; focal dermal hypoplasia; and synostosis (multiple). Orthologous to several human genes including TWIST1 (twist family bHLH transcription factor 1) and TWIST2 (twist family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022] |