hlh-11 (Caenorhabditis elegans)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 WBGene00001955 T046279_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in aging. Predicted to be active in nucleus. Is expressed in several structures, including excretory cell; intestine; male-specific anatomical entity; non-striated muscle; and somatic nervous system. Orthologous to human TFAP4 (transcription factor AP-4). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
hlh-11
M00931_2.00		 Caenorhabditis elegans
ATCAGCTGA
TCAGCTGAT		 PBM
Grove et al.(2009)
HLH11		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
crp
M03595_2.00 		Drosophila melanogaster
AACAGCTGWT
AWCAGCTGTT		 SELEX
Nitta et al.(2015)
crp_1 		0.879 0.750
crp
M05937_2.00 		Drosophila melanogaster
VAHCAGCTGAY
RTCAGCTGDWB		 B1H
Zhu et al.(2011)
crp_SANGER_10_FBgn0001994 		0.879 0.750
For this family, TFs with SR scores > 0.838 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00931_2.00 bHLH 113 164

DNA Binding Domains

Protein ID Domain From To Sequence
F58A4.7a bHLH 111 162
F58A4.7b.1 bHLH 113 164
F58A4.7b.2 bHLH 113 164
F58A4.7c bHLH 111 162

Links

Other bHLH family TFs
Other Caenorhabditis elegans TFs

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44 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action