mxl-3 (Caenorhabditis elegans)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 WBGene00003511 T046299_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in aging; regulation of fatty acid biosynthetic process; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in intestine; neurons; and pharynx. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Orthologous to human MAX (MYC associated factor X). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
mxl-3
M00935_2.00		 Caenorhabditis elegans
RCACGTGS
SCACGTGY		 PBM
Grove et al.(2009)
MXL3		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00935_2.00 bHLH 48 99

DNA Binding Domains

Protein ID Domain From To Sequence
F46G10.6 bHLH 48 99

Links

Other bHLH family TFs
Other Caenorhabditis elegans TFs

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6 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action