RTG3 (Saccharomyces cerevisiae)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 YBL103C T046364_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including autophagy of mitochondrion; cellular response to oleic acid; and mitochondria-nucleus signaling pathway. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Tietz syndrome; Tietze's syndrome; Waardenburg's syndrome (multiple); familial melanoma; and renal cell carcinoma. Orthologous to several human genes including MITF (melanocyte inducing transcription factor) and TFEB (transcription factor EB). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
RTG3
M01518_2.00		 Saccharomyces cerevisiae
NKCACGTGANNN
NNNTCACGTGMN		 PBM
Zhu et al.(2009)
Rtg3		 (Direct) (Direct)
RTG3
M08480_2.00		 Saccharomyces cerevisiae
NRTSACTCDYN
NRHGAGTSAYN		 Misc
DeBoer et al.(2011)
YBL103C_1445		 (Direct) (Direct)
RTG3
M08481_2.00		 Saccharomyces cerevisiae
NGTGACCS
SGGTCACN		 Misc
DeBoer et al.(2011)
YBL103C_1446		 (Direct) (Direct)
RTG3
M08482_2.00		 Saccharomyces cerevisiae
NNVNDDKCACGTGMNBDNHH
DDNHVNKCACGTGMHHNBNN		 Misc
DeBoer et al.(2011)
YBL103C_870		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01518_2.00 bHLH 286 345

DNA Binding Domains

Protein ID Domain From To Sequence
YBL103C bHLH 286 345

Links

Other bHLH family TFs
Other Saccharomyces cerevisiae TFs

5 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
730_YBL103C Saccharomyces paradoxus 730_YBL103C I 0.914
1691_Multiple Saccharomyces mikatae 1691_Multiple I 0.914
1266_YBL103C Saccharomyces bayanus 1266_YBL103C I 0.914
SU7_0054 Saccharomyces arboricola SU7_0054 I 0.914
SKUD_194803 Saccharomyces kudriavzevii SKUD_194803 I 0.914