TF Information

ENSBTAP00000017323-D1 *(Bos grunniens)* bHLH
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source
PF00010 (HLH)	IPR001092	ENSBTAP00000017323-D1	T047141_2.00	GigaDB (2015-Oct-22)
NCBI Gene Info: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
No direct experiments
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Arntl M01751_2.00	Mus musculus	NCACGTGAYN	NRTCACGTGN	PBM Weirauch et al.(2014) pTH5064	0.914	1.000
ARNTL M02787_2.00	Homo sapiens	GTCACGTGAC	GTCACGTGAC	SELEX Jolma et al.(2013) ARNTL_1	0.914	1.000
ARNTL M04124_2.00	Homo sapiens	RDCACGTGHN	NDCACGTGHY	SELEX Yin et al.(2017) ARNTL_eDBD_HT-SELEX	0.914	1.000
ARNTL M08725_2.00	Homo sapiens	NVDCACGTGBN	NVCACGTGHBN	Misc Kulakovskiy et al.(2013) BMAL1_HUMAN.H11MO.0.A	0.914	1.000
Arntl M08776_2.00	Mus musculus	VCACGTGMN	NKCACGTGB	Misc Kulakovskiy et al.(2013) BMAL1_MOUSE.H11MO.0.A	0.914	1.000
Arntl M09478_2.00	Mus musculus	CACGTGNN	NNCACGTG	Misc Heinz et al.(2010) Liver-Bmal1_GSE39860	0.914	1.000
Arntl M09889_2.00	Rattus norvegicus	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$BMAL1_01	0.914	1.000
ARNTL M09841_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$BMAL1_Q6	0.914	1.000
ARNTL M04125_2.00	Homo sapiens	NDCACRTGHY	RDCAYGTGHN	SELEX Yin et al.(2017) ARNTL_eDBD_Methyl-HT-SELEX	0.914	1.000
For this family, TFs with SR scores > 0.838* will likely have a similar motif*