|
ENSBTAP00000021592-D1
(Bos grunniens)
bHLH
|
TF Information |
Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
PF00010 (HLH) |
IPR001092 |
ENSBTAP00000021592-D1 |
T047146_2.00 |
GigaDB (2015-Oct-22) |
NCBI Gene Info:This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016] |
Directly determined binding motifs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
No direct experiments |
|
|
|
|
|
Motifs from related TFs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
ASCL1
M04135_2.00 |
Homo sapiens |
NRCASSTGYN |
NRCASSTGYN |
SELEX
Yin et al.(2017)
ASCL1_eDBD_HT-SELEX
|
0.914
|
1.000
|
ASCL1
M08055_2.00 |
Homo sapiens |
NNRGCAGCTGSNN |
NNSCAGCTGCYNN |
ChIP-seq
Mathelier et al.(2014)
MA1100.1
|
0.914
|
1.000
|
ASCL1
M08730_2.00 |
Homo sapiens |
NNVCASCTGCYBYN |
NRVRGCAGSTGBNN |
Misc
Kulakovskiy et al.(2013)
ASCL1_HUMAN.H11MO.0.A
|
0.914
|
1.000
|
Ascl1
M08748_2.00 |
Mus musculus |
BHSCASCTGCYBBN |
NVVRGCAGSTGSDV |
Misc
Kulakovskiy et al.(2013)
ASCL1_MOUSE.H11MO.0.A
|
0.914
|
1.000
|
Ascl1
M09464_2.00 |
Mus musculus |
NVCABCTGBBNN |
NNVVCAGVTGBN |
Misc
Heinz et al.(2010)
NeuralTubes-Ascl1_GSE55840
|
0.914
|
1.000
|
ASCL1
M09855_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$MASH1_Q6_01
|
0.914
|
1.000
|
ASCL1
M09856_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$MASH1_Q6_02
|
0.914
|
1.000
|
ASCL1
M09857_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$MASH1_Q6
|
0.914
|
1.000
|
ASCL1
M04136_2.00 |
Homo sapiens |
NRCAGCTGYN |
NRCAGCTGYN |
SELEX
Yin et al.(2017)
ASCL1_eDBD_Methyl-HT-SELEX
|
0.914
|
1.000
|
Ascl2
M00117_2.00 |
Mus musculus |
NVCABVTGBN |
NVCABVTGBN |
PBM
Badis et al.(2009)
Ascl2_2654
|
0.871
|
0.880
|
Ascl2
M02814_2.00 |
Mus musculus |
RRCAGCTGYY |
RRCAGCTGYY |
SELEX
Jolma et al.(2013)
Ascl2_1
|
0.871
|
0.880
|
Ascl2
M08744_2.00 |
Mus musculus |
RGCAGSTGB |
VCASCTGCY |
Misc
Kulakovskiy et al.(2013)
ASCL2_MOUSE.H11MO.0.C
|
0.871
|
0.880
|
ASCL2
M04207_2.00 |
Homo sapiens |
NRCAGCTGYN |
NRCAGCTGYN |
SELEX
Yin et al.(2017)
ASCL2_eDBD_HT-SELEX
|
0.871
|
0.860
|
ASCL2
M04209_2.00 |
Homo sapiens |
VCACRACGCD |
HGCGTYGTGB |
SELEX
Yin et al.(2017)
ASCL2_FL_HT-SELEX_1
|
0.871
|
0.860
|
ASCL2
M04210_2.00 |
Homo sapiens |
NRCAGCTGYN |
NRCAGCTGYN |
SELEX
Yin et al.(2017)
ASCL2_FL_HT-SELEX_2
|
0.871
|
0.860
|
ASCL2
M04208_2.00 |
Homo sapiens |
NRCAGCTGYN |
NRCAGCTGYN |
SELEX
Yin et al.(2017)
ASCL2_eDBD_Methyl-HT-SELEX
|
0.871
|
0.860
|
ASCL2
M04211_2.00 |
Homo sapiens |
VRCAGCTGYB |
VRCAGCTGYB |
SELEX
Yin et al.(2017)
ASCL2_FL_Methyl-HT-SELEX
|
0.871
|
0.860
|
For this family, TFs with SR scores > 0.838 will likely have a similar motif |