|
ENSBTAP00000053693-D1
(Bos grunniens)
bHLH
|
TF Information |
Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
PF00010 (HLH) |
IPR001092 |
ENSBTAP00000053693-D1 |
T047162_2.00 |
GigaDB (2015-Oct-22) |
NCBI Gene Info:This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016] |
Directly determined binding motifs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
No direct experiments |
|
|
|
|
|
Motifs from related TFs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
Mitf
M01741_2.00 |
Mus musculus |
NCDCGTGAYN |
NRTCACGHGN |
PBM
Weirauch et al.(2014)
pTH5465
|
0.914
|
1.000
|
MITF
M08058_2.00 |
Homo sapiens |
NNNDRTCACGTGAYHNNN |
NNNDRTCACGTGAYHNNN |
ChIP-seq
Mathelier et al.(2014)
MA0620.2
|
0.914
|
1.000
|
MITF
M08740_2.00 |
Homo sapiens |
YCAYGTGACH |
DGTCACRTGR |
Misc
Kulakovskiy et al.(2013)
MITF_HUMAN.H11MO.0.A
|
0.914
|
1.000
|
Mitf
M08765_2.00 |
Mus musculus |
BCHYGTGACY |
RGTCACRDGV |
Misc
Kulakovskiy et al.(2013)
MITF_MOUSE.H11MO.0.A
|
0.914
|
1.000
|
Mitf
M09475_2.00 |
Mus musculus |
GTCACRWGVB |
VBCWYGTGAC |
Misc
Heinz et al.(2010)
MastCells-MITF_GSE48085
|
0.914
|
1.000
|
MITF
M09880_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$MITF_Q4
|
0.914
|
1.000
|
MITF
M09881_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$MITF_Q6
|
0.914
|
1.000
|
Tfe3
M01715_2.00 |
Mus musculus |
NCDCRTGAYN |
NRTCAYGHGN |
PBM
Weirauch et al.(2014)
pTH5057
|
0.914
|
0.981
|
Tfe3
M05833_2.00 |
Mus musculus |
CACGTGAY |
RTCACGTG |
SMiLE-seq
Isakova et al.(2017)
TFE3
|
0.914
|
0.981
|
Tfe3
M08743_2.00 |
Mus musculus |
TCACGTGACH |
DGTCACGTGA |
Misc
Kulakovskiy et al.(2013)
TFE3_MOUSE.H11MO.0.A
|
0.914
|
0.981
|
Tfe3
M09884_2.00 |
Mus musculus |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$TFEA_01
|
0.914
|
0.981
|
TFE3
M02773_2.00 |
Homo sapiens |
VNCACGTGMY |
RKCACGTGNB |
SELEX
Jolma et al.(2013)
TFE3_1
|
0.871
|
0.963
|
TFE3
M04058_2.00 |
Homo sapiens |
YVCACGTGAYN |
NRTCACGTGBR |
SELEX
Yin et al.(2017)
TFE3_eDBD_HT-SELEX
|
0.871
|
0.963
|
TFE3
M08709_2.00 |
Homo sapiens |
TCACGTGACH |
DGTCACGTGA |
Misc
Kulakovskiy et al.(2013)
TFE3_HUMAN.H11MO.0.B
|
0.871
|
0.963
|
TFE3
M09790_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$TFEA_Q6
|
0.871
|
0.963
|
TFE3
M04059_2.00 |
Homo sapiens |
NRTCACATGBB |
VVCATGTGAYN |
SELEX
Yin et al.(2017)
TFE3_eDBD_Methyl-HT-SELEX
|
0.871
|
0.963
|
Tfec
M00755_2.00 |
Mus musculus |
NNCACGTGNN |
NNCACGTGNN |
PBM
Weirauch et al.(2013)
pTH2885
|
0.870
|
0.926
|
Tfec
M01736_2.00 |
Mus musculus |
NCNCRTGVYN |
NRBCAYGNGN |
PBM
Weirauch et al.(2014)
pTH5065
|
0.870
|
0.926
|
TFEC
M02778_2.00 |
Homo sapiens |
RNCACRTGAB |
VTCAYGTGNY |
SELEX
Jolma et al.(2013)
TFEC_1
|
0.870
|
0.907
|
TFEC
M04078_2.00 |
Homo sapiens |
NVCACGTGACN |
NGTCACGTGBN |
SELEX
Yin et al.(2017)
TFEC_eDBD_HT-SELEX
|
0.870
|
0.907
|
TFEC
M04079_2.00 |
Homo sapiens |
VNCATGTGAYN |
NRTCACATGNB |
SELEX
Yin et al.(2017)
TFEC_eDBD_Methyl-HT-SELEX
|
0.870
|
0.907
|
Tfeb
M01728_2.00 |
Mus musculus |
CWCGTGAY |
RTCACGWG |
PBM
Weirauch et al.(2014)
pTH5072
|
0.855
|
0.889
|
TFEB
M02781_2.00 |
Homo sapiens |
RNCACGTGAY |
RTCACGTGNY |
SELEX
Jolma et al.(2013)
TFEB_1
|
0.855
|
0.889
|
TFEB
M02727_2.00 |
Homo sapiens |
RTCACGTGAY |
RTCACGTGAY |
SELEX
Jolma et al.(2010)
TFEB_dimer
|
0.855
|
0.889
|
TFEB
M04088_2.00 |
Homo sapiens |
YVCACGTGAYN |
NRTCACGTGBR |
SELEX
Yin et al.(2017)
TFEB_eDBD_HT-SELEX
|
0.855
|
0.889
|
TFEB
M08718_2.00 |
Homo sapiens |
CACGTGAYY |
RRTCACGTG |
Misc
Kulakovskiy et al.(2013)
TFEB_HUMAN.H11MO.0.C
|
0.855
|
0.889
|
Tfeb
M08753_2.00 |
Mus musculus |
CACGTGAYY |
RRTCACGTG |
Misc
Kulakovskiy et al.(2013)
TFEB_MOUSE.H11MO.0.C
|
0.855
|
0.889
|
TFEB
M04089_2.00 |
Homo sapiens |
VNCATGTGAYN |
NRTCACATGNB |
SELEX
Yin et al.(2017)
TFEB_eDBD_Methyl-HT-SELEX
|
0.855
|
0.889
|
For this family, TFs with SR scores > 0.838 will likely have a similar motif |