ENSP00000302189 (Macaca fascicularis)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00010 (HLH) IPR001092 ENSP00000302189 T047218_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM, Nov 2002]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
NHLH1
M02796_2.00 		Homo sapiens
CGCAGCTGCB
VGCAGCTGCG		 SELEX
Jolma et al.(2013)
NHLH1_1 		0.914 1.000
NHLH1
M02797_2.00 		Homo sapiens
VGCAGCTGCK
MGCAGCTGCB		 SELEX
Jolma et al.(2013)
NHLH1_2 		0.914 1.000
NHLH1
M04162_2.00 		Homo sapiens
NDGNMKCAGCTGCGYCMH
DKGRCGCAGCTGMKNCHN		 SELEX
Yin et al.(2017)
NHLH1_eDBD_HT-SELEX 		0.914 1.000
NHLH1
M04164_2.00 		Homo sapiens
NDGNMKCAGCTGCGYCMH
DKGRCGCAGCTGMKNCHN		 SELEX
Yin et al.(2017)
NHLH1_FL_HT-SELEX 		0.914 1.000
Nhlh1
M08773_2.00 		Mus musculus
BKGGNMNCAGCTGCGBCCYY
RRGGVCGCAGCTGNKNCCMV		 Misc
Kulakovskiy et al.(2013)
HEN1_MOUSE.H11MO.0.C 		0.914 1.000
NHLH1
M09875_2.00 		Homo sapiens
NNDGGNMVCAGCTGVGNCCNNN
NNNGGNCBCAGCTGBKNCCHNN		 Transfac
Matys et al.(2006)
V$HEN1_01 		0.914 1.000
NHLH1
M09876_2.00 		Homo sapiens
NDRGGVMGCAGCTGMKNCCHHN
NDDGGNMKCAGCTGCKBCCYHN		 Transfac
Matys et al.(2006)
V$HEN1_02 		0.914 1.000
NHLH1
M04163_2.00 		Homo sapiens
NRGBMKCAGCTGCGYCCH
DGGRCGCAGCTGMKVCYN		 SELEX
Yin et al.(2017)
NHLH1_eDBD_Methyl-HT-SELEX 		0.914 1.000
NHLH1
M04165_2.00 		Homo sapiens
DGGNMBCAGCTGCGYCCH
DGGRCGCAGCTGVKNCCH		 SELEX
Yin et al.(2017)
NHLH1_FL_Methyl-HT-SELEX 		0.914 1.000
Nhlh2
M00756_2.00 		Mus musculus
NKCAGCTGHN
NDCAGCTGMN		 PBM
Weirauch et al.(2013)
pTH3037 		0.914 0.981
NHLH2
M04177_2.00 		Homo sapiens
DDGNMGCAGCTGCGYCMH
DKGRCGCAGCTGCKNCHH		 SELEX
Yin et al.(2017)
NHLH2_FL_HT-SELEX 		0.914 0.981
NHLH2
M09878_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HEN2_Q2 		0.914 0.981
NHLH2
M04178_2.00 		Homo sapiens
DGGNMBCAGCTGCGYCCH
DGGRCGCAGCTGVKNCCH		 SELEX
Yin et al.(2017)
NHLH2_FL_Methyl-HT-SELEX 		0.914 0.981
HLH4C
M03609_2.00 		Drosophila melanogaster
DDNCRCAGCTGYGNHH
DDNCRCAGCTGYGNHH		 SELEX
Nitta et al.(2015)
HLH4C_1 		0.891 0.923
HLH4C
M03610_2.00 		Drosophila melanogaster
DRSMYCAGCTGVKSYH
DRSMBCAGCTGRKSYH		 SELEX
Nitta et al.(2015)
HLH4C_2 		0.891 0.923
HLH4C
M03611_2.00 		Drosophila melanogaster
NRBMYCAGCTGYGNHH
DDNCRCAGCTGRKVYN		 SELEX
Nitta et al.(2015)
HLH4C_3 		0.891 0.923
HLH4C
M05963_2.00 		Drosophila melanogaster
CACCTGMDCC
GGHKCAGGTG		 B1H
Zhu et al.(2011)
HLH4C_da_SANGER_5_3_FBgn0011277 		0.891 0.923
HLH4C
M05964_2.00 		Drosophila melanogaster
MCAYCTGMGMMM
KKKCKCAGRTGK		 B1H
Zhu et al.(2011)
HLH4C_da_SANGER_5_4_FBgn0011277 		0.891 0.923
HLH4C
M05965_2.00 		Drosophila melanogaster
VNHHVCACCTGMBNC
GNVKCAGGTGBDDNB		 B1H
Zhu et al.(2011)
HLH4C_da_SANGER_5_FBgn0011277 		0.891 0.923
HLH4C
M05966_2.00 		Drosophila melanogaster
RGSMYCAGCTGCGYY
RRCGCAGCTGRKSCY		 B1H
Zhu et al.(2011)
HLH4C_SANGER_5_FBgn0011277 		0.891 0.923
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000302189 bHLH 76 128

Links

Other bHLH family TFs
Other Macaca fascicularis TFs

170 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
AAEL004428 Aedes aegypti AAEL004428 I 0.894
AALB004585 Anopheles albimanus AALB004585 I 0.894
Aan_R014318 Calypte anna Aan_R014318 I 0.894
AARA003512 Anopheles arabiensis AARA003512 I 0.894
AATE010880 Anopheles atroparvus AATE010880 I 0.894
ACAC_0000390701 Angiostrongylus cantonensis ACAC_0000390701 I 0.851
ACEP10202 Atta cephalotes ACEP10202 I 0.914
ACOM036372 Anopheles coluzzii ACOM036372 I 0.894
ACUA009159 Anopheles culicifacies ACUA009159 I 0.894
ACUA026679 Anopheles culicifacies ACUA026679 I 0.894
ACYPI007008 Acyrthosiphon pisum ACYPI007008 I 0.894
ADAC006978 Anopheles darlingi ADAC006978 I 0.894
ADIR001683 Anopheles dirus ADIR001683 I 0.894
AEPI011485 Anopheles epiroticus AEPI011485 I 0.894
AFAF009162 Anopheles farauti AFAF009162 I 0.894
AFUN005050 Anopheles funestus AFUN005050 I 0.894
AGAP004907 Anopheles gambiae AGAP004907 I 0.894
Alligator_sinensis_CCG011163.1 Alligator sinensis Alligator_sinensis_CCG011163.1 I 0.914
Alligator_sinensis_CCG018876.1 Alligator sinensis Alligator_sinensis_CCG018876.1 I 0.894
AMAM022568 Anopheles maculatus AMAM022568 I 0.894
AMEC009920 Anopheles melas AMEC009920 I 0.894
AMEM004741 Anopheles merus AMEM004741 I 0.894
AMIN011405 Anopheles minimus AMIN011405 I 0.894
AQUA014034 Anopheles quadriannulatus AQUA014034 I 0.894
ASIS019843 Anopheles sinensis ASIS019843 I 0.894
ASTEI10641 Anopheles stephensi ASTEI10641 I 0.894
BGIBMGA008476 Bombyx mori BGIBMGA008476 I 0.894
BGLB013717 Biomphalaria glabrata BGLB013717 I 0.894
Brh_R005283 Buceros rhinoceros Brh_R005283 I 0.861
BXY_0231500 Bursaphelenchus xylophilus BXY_0231500 I 0.864
CapteG162858 Capitella teleta CapteG162858 I 0.894
Cflo_11933--XP_001122281.1_APIME Camponotus floridanus Cflo_11933--XP_001122281.1_APIME I 0.914
CGI_10002829 Crassostrea gigas CGI_10002829 I 0.870
CLEC002464 Cimex lectularius CLEC002464 I 0.894
Cmyd_10001044 Chelonia mydas Cmyd_10001044 I 0.882
Cmyd_10010324 Chelonia mydas Cmyd_10010324 I 0.894
Cmyd_10014342 Chelonia mydas Cmyd_10014342 I 0.914
DAPPUDRAFT_66944 Daphnia pulex DAPPUDRAFT_66944 I 0.894
ENSACAG00000010649 Anolis carolinensis ENSACAG00000010649 I 0.894
ENSAMEG00000010851 Ailuropoda melanoleuca ENSAMEG00000010851 I 0.890
ENSAMXG00000026006 Astyanax mexicanus ENSAMXG00000026006 I 0.894
ENSCSAG00000000087 Chlorocebus sabaeus ENSCSAG00000000087 I 0.914
ENSCSAG00000000172 Chlorocebus sabaeus ENSCSAG00000000172 I 0.914
ENSFALG00000006103 Ficedula albicollis ENSFALG00000006103 I 0.914
ENSFCAG00000028313 Felis catus ENSFCAG00000028313 I 0.914
ENSGMOG00000020309 Gadus morhua ENSGMOG00000020309 I 0.894
ENSLACG00000011363 Latimeria chalumnae ENSLACG00000011363 I 0.914
ENSLOCG00000017787 Lepisosteus oculatus ENSLOCG00000017787 I 0.894
ENSMEUG00000003022 Macropus eugenii ENSMEUG00000003022 I 0.914
ENSMGAG00000016096 Meleagris gallopavo ENSMGAG00000016096 I 0.894
ENSMICG00000002851 Microcebus murinus ENSMICG00000002851 I 0.914
ENSMMUG00000008971 Macaca mulatta ENSMMUG00000008971 I 0.914
ENSMPUG00000019387 Mustela putorius furo ENSMPUG00000019387 I 0.914
ENSMPUG00000019473 Mustela putorius furo ENSMPUG00000019473 I 0.914
ENSNLEG00000013637 Nomascus leucogenys ENSNLEG00000013637 I 0.914
ENSONIG00000020673 Oreochromis niloticus ENSONIG00000020673 I 0.866
ENSONIG00000021015 Oreochromis niloticus ENSONIG00000021015 I 0.894
ENSP00000358519-D1 Bos grunniens ENSP00000358519-D1 I 0.914
ENSP00000405915 Macaca fascicularis ENSP00000405915 I 0.914
ENSPANG00000001481 Papio anubis ENSPANG00000001481 I 0.914
ENSPANG00000011970 Papio anubis ENSPANG00000011970 I 0.914
ENSPFOG00000020651 Poecilia formosa ENSPFOG00000020651 I 0.894
ENSPPYG00000000632 Pongo abelii ENSPPYG00000000632 I 0.914
ENSPPYG00000000988 Pongo abelii ENSPPYG00000000988 I 0.914
ENSSHAG00000006613 Sarcophilus harrisii ENSSHAG00000006613 I 0.914
ENSSHAG00000015472 Sarcophilus harrisii ENSSHAG00000015472 I 0.914
ENSSTOG00000019698 Ictidomys tridecemlineatus ENSSTOG00000019698 I 0.914
ENSSTOG00000027988 Ictidomys tridecemlineatus ENSSTOG00000027988 I 0.914
ENSTSYG00000000582 Tarsius syrichta ENSTSYG00000000582 I 0.914
ENSXMAG00000020348 Xiphophorus maculatus ENSXMAG00000020348 I 0.894
GA15893 Drosophila pseudoobscura FBgn0075909 I 0.891
GB49291 Apis mellifera GB49291 I 0.914
GB53325 Apis mellifera GB53325 I 0.914
GD16284 Drosophila simulans FBgn0187911 I 0.891
GE16844 Drosophila yakuba FBgn0234336 I 0.891
GF20856 Drosophila ananassae FBgn0097862 I 0.891
Gfo_R014815 Geospiza fortis Gfo_R014815 I 0.894
GG18528 Drosophila erecta FBgn0110741 I 0.891
GH17630 Drosophila grimshawi FBgn0125100 I 0.891
GI16068 Drosophila mojavensis FBgn0138817 I 0.891
GJ15714 Drosophila virilis FBgn0202902 I 0.891
GK16457 Drosophila willistoni FBgn0218459 I 0.891
GL14555 Drosophila persimilis FBgn0152160 I 0.891
GM12676 Drosophila sechellia FBgn0167612 I 0.891
HelroG138545 Helobdella robusta HelroG138545 I 0.914
HelroG153470 Helobdella robusta HelroG153470 I 0.870
HelroG94416 Helobdella robusta HelroG94416 I 0.870
HHAL001761-PA Halyomorpha halys HHAL001761-PA I 0.894
HLH4C Drosophila melanogaster FBgn0011277 D 0.891
HMEL010237 Heliconius melpomene HMEL010237 I 0.838
HPBE_0000907401 Heligmosomoides bakeri HPBE_0000907401 I 0.851
Hsal_11874--XP_001122281.1_APIME Harpegnathos saltator Hsal_11874--XP_001122281.1_APIME I 0.914
ISCW014797 Ixodes scapularis ISCW014797 I 0.894
KGM_06532 Danaus plexippus KGM_06532 I 0.894
L798_00559 Zootermopsis nevadensis L798_00559 I 0.894
LCUP012274 Lucilia cuprina LCUP012274 I 0.891
LDEC000946 Leptinotarsa decemlineata LDEC000946 I 0.894
LLOJ002704 Lutzomyia longipalpis LLOJ002704 I 0.894
LotgiG133561 Lottia gigantea LotgiG133561 I 0.894
MCINX015834 Melitaea cinxia MCINX015834 I 0.894
MDOA007431 Musca domestica MDOA007431 I 0.891
MDOA013398 Musca domestica MDOA013398 I 0.891
MESCA010279 Megaselia scalaris MESCA010279 I 0.867
NHLH1 Otolemur garnettii ENSOGAG00000010592 I 0.914
NHLH1 Procavia capensis ENSPCAG00000009061 I 0.914
NHLH1 Homo sapiens ENSG00000171786 D 0.914
NHLH1 Echinops telfairi ENSETEG00000009677 I 0.914
NHLH1 Loxodonta africana ENSLAFG00000011163 I 0.914
NHLH1 Gorilla gorilla ENSGGOG00000015736 I 0.914
NHLH1 Equus caballus ENSECAG00000004612 I 0.914
NHLH1 Gallus gallus ENSGALG00000025817 I 0.894
NHLH1 Monodelphis domestica ENSMODG00000024591 I 0.914
NHLH1 Macaca mulatta ENSMMUG00000021865 I 0.914
nhlh1 Xenopus tropicalis XB-GENE-989790 I 0.914
NHLH1 Microcebus murinus ENSMICG00000012700 I 0.914
Nhlh1 Mus musculus ENSMUSG00000051251 D 0.914
NHLH1 Tursiops truncatus ENSTTRG00000001840 I 0.914
NHLH1 Cavia porcellus ENSCPOG00000021596 I 0.914
NHLH1 Taeniopygia guttata ENSTGUG00000013389 I 0.914
NHLH1 Sus scrofa ENSSSCG00000006384 I 0.914
NHLH1 Callithrix jacchus ENSCJAG00000005775 I 0.914
NHLH1 Canis familiaris ENSCAFG00000023513 I 0.914
Nhlh1 Rattus norvegicus ENSRNOG00000005166 I 0.914
NHLH1 Dasypus novemcinctus ENSDNOG00000038600 I 0.914
NHLH1 Pteropus vampyrus ENSPVAG00000007987 I 0.914
NHLH1 Pan troglodytes ENSPTRG00000001551 I 0.914
NHLH1 Bos taurus ENSBTAG00000020027 I 0.914
nhlh1.L Xenopus laevis XB-GENE-989792 I 0.914
nhlh1.S Xenopus laevis XB-GENE-6252028 I 0.914
NHLH2 Cavia porcellus ENSCPOG00000026593 I 0.914
NHLH2 Dasypus novemcinctus ENSDNOG00000008961 I 0.914
NHLH2 Callithrix jacchus ENSCJAG00000012807 I 0.914
nhlh2 Danio rerio ENSDARG00000025495 I 0.894
NHLH2 Anolis carolinensis ENSACAG00000003304 I 0.914
NHLH2 Homo sapiens ENSG00000177551 D 0.914
NHLH2 Bos taurus ENSBTAG00000015067 I 0.914
NHLH2 Canis familiaris ENSCAFG00000009767 I 0.914
nhlh2 Gasterosteus aculeatus ENSGACG00000014053 I 0.894
nhlh2 Takifugu rubripes ENSTRUG00000003636 I 0.894
nhlh2 Tetraodon nigroviridis ENSTNIG00000010331 I 0.894
NHLH2 Sus scrofa ENSSSCG00000006744 I 0.914
NHLH2 Otolemur garnettii ENSOGAG00000034540 I 0.914
Nhlh2 Rattus norvegicus ENSRNOG00000054375 I 0.914
NHLH2 Pteropus vampyrus ENSPVAG00000012688 I 0.914
NHLH2 Pan troglodytes ENSPTRG00000001149 I 0.914
NHLH2 Ochotona princeps ENSOPRG00000006661 I 0.914
NHLH2 Loxodonta africana ENSLAFG00000007456 I 0.914
NHLH2 Gorilla gorilla ENSGGOG00000008283 I 0.914
NHLH2 Oryctolagus cuniculus ENSOCUG00000015744 I 0.914
NHLH2 Ornithorhynchus anatinus ENSOANG00000009820 I 0.914
Nhlh2 Mus musculus ENSMUSG00000048540 D 0.914
NHLH2 Monodelphis domestica ENSMODG00000023228 I 0.914
NHLH2 Myotis lucifugus ENSMLUG00000015989 I 0.914
NHLH2 Tursiops truncatus ENSTTRG00000003112 I 0.914
nRc.2.0.1.g35713 Romanomermis culicivorax nRc.2.0.1.g35713 I 0.870
NV10733 Nasonia vitripennis NV10733 I 0.914
Ocbimv22001940m.g Octopus bimaculoides Ocbimv22001940m.g I 0.894
Ogr08231 Ophisaurus gracilis Ogr08231 I 0.894
PHUM229200 Pediculus humanus PHUM229200 I 0.894
PPAI007861 Phlebotomus papatasi PPAI007861 I 0.894
Pvit_07565 Pogona vitticeps Pvit_07565 I 0.894
RPRC001173 Rhodnius prolixus RPRC001173 I 0.894
Sakowv30004475m.g Saccoglossus kowalevskii Sakowv30004475m.g I 0.894
SMAR007908 Strigamia maritima SMAR007908 I 0.894
SMU15030866 Schmidtea mediterranea SMU15030866 I 0.857
SPU_009231 Strongylocentrotus purpuratus SPU_009231 I 0.894
TC007725 Tribolium castaneum TC007725 I 0.894
YQE_00442 Dendroctonus ponderosae YQE_00442 I 0.894
YQE_04623 Dendroctonus ponderosae YQE_04623 I 0.894
YQE_11502 Dendroctonus ponderosae YQE_11502 I 0.894