ENSP00000331057 (Macaca fascicularis)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00010 (HLH) IPR001092 ENSP00000331057 T047234_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Tcf12
M01740_2.00
Mus musculus
NVCAYCTGB

VCAGRTGBN
PBM
Weirauch et al.(2014)
pTH5071
0.914 1.000
TCF12
M04137_2.00
Homo sapiens
VCACSTGB

VCASGTGB
SELEX
Yin et al.(2017)
TCF12_eDBD_HT-SELEX
0.914 1.000
Tcf12
M08062_2.00
Mus musculus
RRCAGCTGNNN

NNNCAGCTGYY
ChIP-seq
Mathelier et al.(2014)
MA0521.1
0.914 1.000
TCF12
M07805_2.00
Homo sapiens
NVDSCAGSTGB

VCASCTGSHBN
ChIP-seq
Gerstein et al.(2012)
GM12878_TCF12_HudsonAlpha
0.914 1.000
TCF12
M07806_2.00
Homo sapiens
VCASCTGB

VCAGSTGB
ChIP-seq
Gerstein et al.(2012)
H1-hESC_TCF12_HudsonAlpha
0.914 1.000
TCF12
M08731_2.00
Homo sapiens
CMCASCTGSH

DSCAGSTGKG
Misc
Kulakovskiy et al.(2013)
HTF4_HUMAN.H11MO.0.A
0.914 1.000
Tcf12
M08762_2.00
Mus musculus
VMCASCTGSH

DSCAGSTGKB
Misc
Kulakovskiy et al.(2013)
HTF4_MOUSE.H11MO.0.A
0.914 1.000
TCF12
M09458_2.00
Homo sapiens
NNVCAGCTGB

VCAGCTGBNN
Misc
Heinz et al.(2010)
GM12878-Tcf12_GSE32465
0.914 1.000
TCF12
M09858_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HEB_Q6
0.914 1.000
TCF12
M09859_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HTF4_Q2
0.914 1.000
TCF12
M09860_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TCF12_01
0.914 1.000
TCF12
M09861_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TCF12_03
0.914 1.000
TCF12
M09862_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TCF12_05
0.914 1.000
TCF12
M04138_2.00
Homo sapiens
NCAYCTGN

NCAGRTGN
SELEX
Yin et al.(2017)
TCF12_eDBD_Methyl-HT-SELEX
0.914 1.000
Tcf3
M00753_2.00
Mus musculus
VCACCTGBN

NVCAGGTGB
PBM
Weirauch et al.(2013)
pTH3866
0.914 0.885
Tcf3
M01723_2.00
Mus musculus
NNVCACSTGB

VCASGTGBNN
PBM
Weirauch et al.(2014)
pTH4580
0.914 0.885
Tcf3
M00118_2.00
Mus musculus
VCAYCTGB

VCAGRTGB
PBM
Badis et al.(2009)
Tcfe2a_3865
0.914 0.885
Tcf4
M01750_2.00
Mus musculus
VCAGVTGBN

NVCABCTGB
PBM
Weirauch et al.(2014)
pTH5101
0.912 0.962
TCF4
M02807_2.00
Homo sapiens
HRCACCTGBN

NVCAGGTGYD
SELEX
Jolma et al.(2013)
TCF4_1
0.912 0.962
TCF4
M02808_2.00
Homo sapiens
NVCACCTBBN

NVVAGGTGBN
SELEX
Jolma et al.(2013)
TCF4_2
0.912 0.962
TCF4
M02728_2.00
Homo sapiens
RCACCTG

CAGGTGY
SELEX
Jolma et al.(2010)
TCF4_dimer
0.912 0.962
TCF4
M04214_2.00
Homo sapiens
VCACCTGB

VCAGGTGB
SELEX
Yin et al.(2017)
TCF4_eDBD_HT-SELEX
0.912 0.962
Tcf4
M08775_2.00
Mus musculus
HRCACCTGB

VCAGGTGYD
Misc
Kulakovskiy et al.(2013)
ITF2_MOUSE.H11MO.0.B
0.912 0.962
TCF4
M09461_2.00
Homo sapiens
ASWTCAAAGRVN

NBYCTTTGAWST
Misc
Heinz et al.(2010)
Hct116-Tcf4_SRA012054
0.912 0.962
TCF4
M04215_2.00
Homo sapiens
VCACCTGN

NCAGGTGB
SELEX
Yin et al.(2017)
TCF4_eDBD_Methyl-HT-SELEX
0.912 0.962
Tcf3
M09465_2.00
Mus musculus
ABWTCAAAGS

SCTTTGAWVT
Misc
Heinz et al.(2010)
mES-Tcf3_GSE11724
0.886 0.962
Tcf3
M09466_2.00
Mus musculus
VCAGCTGBNN

NNVCAGCTGB
Misc
Heinz et al.(2010)
proBcell-E2A_GSE21978
0.886 0.962
Tcf3
M09886_2.00
Mus musculus Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$E47_05
0.886 0.962
TCF3
M02775_2.00
Homo sapiens
NVCACCTGBN

NVCAGGTGBN
SELEX
Jolma et al.(2013)
TCF3_1
0.886 0.923
TCF3
M08710_2.00
Homo sapiens
VVCASCTGCHN

NDGCAGSTGBB
Misc
Kulakovskiy et al.(2013)
TFE2_HUMAN.H11MO.0.A
0.886 0.923
TCF3
M09791_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$E12_Q6
0.886 0.923
TCF3
M09792_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$E2A_Q6_01
0.886 0.923
TCF3
M09793_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$E2A_Q6_02
0.886 0.923
TCF3
M09794_2.00
Homo sapiens
VVVVMCACCTGCNBB

VVNGCAGGTGKBBBB
Transfac
Matys et al.(2006)
V$E47_01
0.886 0.923
TCF3
M09795_2.00
Homo sapiens
NNKWRCACCTGYDNNN

NNNHRCAGGTGYWMNN
Transfac
Matys et al.(2006)
V$E47_02
0.886 0.923
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000331057 bHLH 602 655

Links

Other bHLH family TFs
Other Macaca fascicularis TFs

212 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ARB_00856 Arthroderma benhamiae ARB_00856 N 0.000
ACLA_003590 Aspergillus clavatus CADACLAG00000238 N 0.000
CADAFLAG00001860 Aspergillus flavus CADAFLAG00001860 N 0.000
AFUA_5G01730 Aspergillus fumigatus CADAFUAG00002744 N 0.000
CADANGAG00012618 Aspergillus niger CADANGAG00012618 N 0.000
CADAORAG00001875 Aspergillus oryzae CADAORAG00001875 N 0.000
NFIA_040370 Neosartorya fischeri CADNFIAG00003632 N 0.000
CIMG_06386 Coccidioides immitis CIMG_06386 N 0.000
CPC735_028920 Coccidioides posadasii CPC735_028920 N 0.000
EURHEDRAFT_381732 Aspergillus ruber EURHEDRAFT_381732 N 0.000
fgenesh1_pg.00168_#_82 Aspergillus carbonarius fgenesh1_pg.00168_#_82 N 0.000
H101_01802 Trichophyton interdigitale H101_01802 N 0.000
H102_04655 Trichophyton rubrum H102_04655 N 0.000
H105_04676 Trichophyton soudanense H105_04676 N 0.000
MCYG_01983 Microsporum canis MCYG_01983 N 0.000
MCYG_01983 Arthroderma otae MCYG_01983 N 0.000
MGYG_04100 Microsporum gypseum MGYG_04100 N 0.000
Pc21g14300 Penicillium chrysogenum Pc21g14300 N 0.000
PCH_Pc21g14300 Penicillium rubens PCH_Pc21g14300 N 0.000
PDE_09981 Penicillium oxalicum PDE_09981 N 0.000
PDIP_47630 Penicillium digitatum PDIP_47630 N 0.000
PEX1_104040 Penicillium expansum PEX1_104040 N 0.000
PITC_021640 Penicillium italicum PITC_021640 N 0.000
PMAA_039470 Penicillium marneffei PMAA_039470 N 0.000
PMAA_039470 Talaromyces marneffei PMAA_039470 N 0.000
PVAR5_8657 Byssochlamys spectabilis PVAR5_8657 N 0.000
TEQG_03206 Trichophyton equinum TEQG_03206 N 0.000
TESG_00428 Trichophyton tonsurans TESG_00428 N 0.000
TRV_07515 Trichophyton verrucosum TRV_07515 N 0.000
TSTA_079360 Talaromyces stipitatus TSTA_079360 N 0.000
U727_00431520221 Penicillium solitum U727_00431520221 N 0.000
UREG_04016 Uncinocarpus reesii UREG_04016 N 0.000