ENSP00000351490 (Macaca fascicularis)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00010 (HLH) IPR001092 ENSP00000351490 T047257_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
MAX
M00938_2.00
Homo sapiens
CCACGTGH

DCACGTGG
PBM
Guo et al.(2014)
Max_L
0.914 1.000
Max
M00121_2.00
Mus musculus
NCRCRTGNN

NNCAYGYGN
PBM
Badis et al.(2009)
Max_3863
0.914 1.000
Max
M00122_2.00
Mus musculus
NNCRCRTGN

NCAYGYGNN
PBM
Badis et al.(2009)
Max_3864
0.914 1.000
Max
M01753_2.00
Mus musculus
NCAYGYKNN

NNMRCRTGN
PBM
Weirauch et al.(2014)
pTH4381
0.914 1.000
Max
M08778_2.00
Mus musculus
VVVCACGYGSN

NSCRCGTGBBB
Misc
Kulakovskiy et al.(2013)
MAX_MOUSE.H11MO.0.A
0.914 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000351490 bHLH 24 75

Links

Other bHLH family TFs
Other Macaca fascicularis TFs

113 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSPANG00000020361 Papio anubis ENSPANG00000020361 I 0.914
MAX Ochotona princeps ENSOPRG00000016245 I 0.914
MAX Procavia capensis ENSPCAG00000000840 I 0.914
ENSPFOG00000013150 Poecilia formosa ENSPFOG00000013150 I 0.914
ENSPSIG00000009674 Pelodiscus sinensis ENSPSIG00000009674 I 0.914
ENSPPYG00000005911 Pongo abelii ENSPPYG00000005911 I 0.914
MAX Oryctolagus cuniculus ENSOCUG00000014439 I 0.914
Alligator_sinensis_CCG022139.1 Alligator sinensis Alligator_sinensis_CCG022139.1 I 0.914
MAX Monodelphis domestica ENSMODG00000009712 I 0.914
MAX Macaca mulatta ENSMMUG00000004341 I 0.914
ENSMPUG00000006859 Mustela putorius furo ENSMPUG00000006859 I 0.914
Max Mus musculus ENSMUSG00000059436 D 0.914
MAX Ornithorhynchus anatinus ENSOANG00000005841 I 0.914
ENSNLEG00000014373 Nomascus leucogenys ENSNLEG00000014373 I 0.914
MAX Pan troglodytes ENSPTRG00000006449 I 0.914
Max Rattus norvegicus ENSRNOG00000008049 I 0.914
Pvit_16227 Pogona vitticeps Pvit_16227 I 0.914
max.L Xenopus laevis XB-GENE-6252877 I 0.914
Ogr08511 Ophisaurus gracilis Ogr08511 I 0.914
Myotis_brandtii_MAX_10027131 Myotis brandtii Myotis_brandtii_MAX_10027131 I 0.914
Cmyd_10004970 Chelonia mydas Cmyd_10004970 I 0.914
ENSBTAP00000023939-D1 Bos grunniens ENSBTAP00000023939-D1 I 0.914
max Xenopus tropicalis XB-GENE-6258209 I 0.914
ENSXMAG00000014355 Xiphophorus maculatus ENSXMAG00000014355 I 0.914
ENSSHAG00000014285 Sarcophilus harrisii ENSSHAG00000014285 I 0.914
MAX Sorex araneus ENSSARG00000010212 I 0.914
ENSSSCG00000002282 Sus scrofa ENSSSCG00000002282 I 0.914
ENSSTOG00000028142 Ictidomys tridecemlineatus ENSSTOG00000028142 I 0.914
MAX Tursiops truncatus ENSTTRG00000002693 I 0.914
ENSTSYG00000007582 Tarsius syrichta ENSTSYG00000007582 I 0.914
MAX Myotis lucifugus ENSMLUG00000004318 I 0.914
ENSOARG00000021159 Ovis aries ENSOARG00000021159 I 0.914
ENSDNOG00000034422 Dasypus novemcinctus ENSDNOG00000034422 I 0.914
MAX Equus caballus ENSECAG00000006923 I 0.914
MAX Erinaceus europaeus ENSEEUG00000003973 I 0.914
MAX Echinops telfairi ENSETEG00000002967 I 0.914
ENSCSAG00000013429 Chlorocebus sabaeus ENSCSAG00000013429 I 0.914
ENSCPOG00000010172 Cavia porcellus ENSCPOG00000010172 I 0.914
ENSAMEG00000003472 Ailuropoda melanoleuca ENSAMEG00000003472 I 0.914
MAX Canis familiaris ENSCAFG00000016212 I 0.914
MAX Choloepus hoffmanni ENSCHOG00000006957 I 0.914
ENSMICG00000013124 Microcebus murinus ENSMICG00000013124 I 0.914
ENSFALG00000001190 Ficedula albicollis ENSFALG00000001190 I 0.914
MAX Callithrix jacchus ENSCJAG00000019702 I 0.914
MAX Gorilla gorilla ENSGGOG00000026047 I 0.914
MAX Felis catus ENSFCAG00000010347 I 0.914
MAX Loxodonta africana ENSLAFG00000018437 I 0.914
MAX Meleagris gallopavo ENSMGAG00000004785 I 0.914
ENSGALG00000028248 Gallus gallus ENSGALG00000028248 I 0.914
ENSLACG00000016665 Latimeria chalumnae ENSLACG00000016665 I 0.914
MAX Homo sapiens ENSG00000125952 D 0.914
NEMVEDRAFT_v1g80696 Nematostella vectensis NEMVEDRAFT_v1g80696 I 0.912
AFAF015236 Anopheles farauti AFAF015236 I 0.903
AALB008732 Anopheles albimanus AALB008732 I 0.903
AARA001274 Anopheles arabiensis AARA001274 I 0.903
NV15216 Nasonia vitripennis NV15216 I 0.903
CPIJ003297 Culex quinquefasciatus CPIJ003297 I 0.903
ACEP16358 Atta cephalotes ACEP16358 I 0.903
AAEL012237 Aedes aegypti AAEL012237 I 0.903
ACYPI005523 Acyrthosiphon pisum ACYPI005523 I 0.903
AGAP003177 Anopheles gambiae AGAP003177 I 0.903
ASTEI00681 Anopheles stephensi ASTEI00681 I 0.903
AMIN002759 Anopheles minimus AMIN002759 I 0.903
ACHR003925 Anopheles christyi ACHR003925 I 0.903
AMEC003172 Anopheles melas AMEC003172 I 0.903
AFUN000621 Anopheles funestus AFUN000621 I 0.903
AMEM013272 Anopheles merus AMEM013272 I 0.903
AQUA008115 Anopheles quadriannulatus AQUA008115 I 0.903
ASIS001309 Anopheles sinensis ASIS001309 I 0.903
CpipJ_CPIJ003297 Culex pipiens CpipJ_CPIJ003297 I 0.903
ACOM035641 Anopheles coluzzii ACOM035641 I 0.903
AEPI003923 Anopheles epiroticus AEPI003923 I 0.903
ACUA001438 Anopheles culicifacies ACUA001438 I 0.903
ADIR006501 Anopheles dirus ADIR006501 I 0.903
MAX Tupaia belangeri ENSTBEG00000012645 I 0.902
Sakowv30027986m.g Saccoglossus kowalevskii Sakowv30027986m.g I 0.884
max.S Xenopus laevis XB-GENE-6255913 I 0.884
MAX Tetraodon nigroviridis ENSTNIG00000000407 I 0.884
MAX Oryzias latipes ENSORLG00000016817 I 0.884
max Gasterosteus aculeatus ENSGACG00000007808 I 0.884
ENSPFOG00000017744 Poecilia formosa ENSPFOG00000017744 I 0.884
max Tetraodon nigroviridis ENSTNIG00000016412 I 0.884
max Takifugu rubripes ENSTRUG00000017815 I 0.884
MAX Takifugu rubripes ENSTRUG00000014760 I 0.884
max Danio rerio ENSDARG00000024844 I 0.884
ENSGMOG00000003647 Gadus morhua ENSGMOG00000003647 I 0.884
SPU_022163 Strongylocentrotus purpuratus SPU_022163 I 0.884
ENSAMXG00000012675 Astyanax mexicanus ENSAMXG00000012675 I 0.884
ISCW013570 Ixodes scapularis ISCW013570 I 0.883
tetur05g05490 Tetranychus urticae tetur05g05490 I 0.875
LLOJ003470 Lutzomyia longipalpis LLOJ003470 I 0.875
Cflo_05278--XP_623530.1_APIME Camponotus floridanus Cflo_05278--XP_623530.1_APIME I 0.873
KGM_17406 Danaus plexippus KGM_17406 I 0.873
Hsal_16014--XP_623530.1_APIME Harpegnathos saltator Hsal_16014--XP_623530.1_APIME I 0.873
GB41968 Apis mellifera GB41968 I 0.873
SINV12716 Solenopsis invicta SINV12716 I 0.873
BGIBMGA004944 Bombyx mori BGIBMGA004944 I 0.873
RPRC015255 Rhodnius prolixus RPRC015255 I 0.873
LotgiG133235 Lottia gigantea LotgiG133235 I 0.870
HHAL010192-PA Halyomorpha halys HHAL010192-PA I 0.869
MDOA012035 Musca domestica MDOA012035 I 0.866
LCUP011850 Lucilia cuprina LCUP011850 I 0.866
fgenesh2_pg.scaffold_132000064 Branchiostoma floridae fgenesh2_pg.scaffold_132000064 I 0.864
gw.35.272.1 Branchiostoma floridae gw.35.272.1 I 0.864
ENSCSAVG00000010547 Ciona savignyi ENSCSAVG00000010547 I 0.857
TriadG51792 Trichoplax adhaerens TriadG51792 I 0.857
CLEC011217 Cimex lectularius CLEC011217 I 0.849
YQE_10562 Dendroctonus ponderosae YQE_10562 I 0.849
TC009976 Tribolium castaneum TC009976 I 0.845
PHUM220200 Pediculus humanus PHUM220200 I 0.845
LDEC015014 Leptinotarsa decemlineata LDEC015014 I 0.845
ENSOGAG00000034529 Otolemur garnettii ENSOGAG00000034529 I 0.842
Ocbimv22020257m.g Octopus bimaculoides Ocbimv22020257m.g I 0.840