ENSP00000378813 (Macaca fascicularis)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00010 (HLH) IPR001092 ENSP00000378813 T047279_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
TCF3
M02775_2.00
Homo sapiens
NVCACCTGBN

NVCAGGTGBN
SELEX
Jolma et al.(2013)
TCF3_1
0.914 1.000
TCF3
M08710_2.00
Homo sapiens
VVCASCTGCHN

NDGCAGSTGBB
Misc
Kulakovskiy et al.(2013)
TFE2_HUMAN.H11MO.0.A
0.914 1.000
TCF3
M09791_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$E12_Q6
0.914 1.000
TCF3
M09792_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$E2A_Q6_01
0.914 1.000
TCF3
M09793_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$E2A_Q6_02
0.914 1.000
TCF3
M09794_2.00
Homo sapiens
VVVVMCACCTGCNBB

VVNGCAGGTGKBBBB
Transfac
Matys et al.(2006)
V$E47_01
0.914 1.000
TCF3
M09795_2.00
Homo sapiens
NNKWRCACCTGYDNNN

NNNHRCAGGTGYWMNN
Transfac
Matys et al.(2006)
V$E47_02
0.914 1.000
Tcf3
M09465_2.00
Mus musculus
ABWTCAAAGS

SCTTTGAWVT
Misc
Heinz et al.(2010)
mES-Tcf3_GSE11724
0.886 0.942
Tcf3
M09466_2.00
Mus musculus
VCAGCTGBNN

NNVCAGCTGB
Misc
Heinz et al.(2010)
proBcell-E2A_GSE21978
0.886 0.942
Tcf3
M09886_2.00
Mus musculus Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$E47_05
0.886 0.942
Tcf12
M01740_2.00
Mus musculus
NVCAYCTGB

VCAGRTGBN
PBM
Weirauch et al.(2014)
pTH5071
0.886 0.923
TCF12
M04137_2.00
Homo sapiens
VCACSTGB

VCASGTGB
SELEX
Yin et al.(2017)
TCF12_eDBD_HT-SELEX
0.886 0.923
Tcf12
M08062_2.00
Mus musculus
RRCAGCTGNNN

NNNCAGCTGYY
ChIP-seq
Mathelier et al.(2014)
MA0521.1
0.886 0.923
TCF12
M07805_2.00
Homo sapiens
NVDSCAGSTGB

VCASCTGSHBN
ChIP-seq
Gerstein et al.(2012)
GM12878_TCF12_HudsonAlpha
0.886 0.923
TCF12
M07806_2.00
Homo sapiens
VCASCTGB

VCAGSTGB
ChIP-seq
Gerstein et al.(2012)
H1-hESC_TCF12_HudsonAlpha
0.886 0.923
TCF12
M08731_2.00
Homo sapiens
CMCASCTGSH

DSCAGSTGKG
Misc
Kulakovskiy et al.(2013)
HTF4_HUMAN.H11MO.0.A
0.886 0.923
Tcf12
M08762_2.00
Mus musculus
VMCASCTGSH

DSCAGSTGKB
Misc
Kulakovskiy et al.(2013)
HTF4_MOUSE.H11MO.0.A
0.886 0.923
TCF12
M09458_2.00
Homo sapiens
NNVCAGCTGB

VCAGCTGBNN
Misc
Heinz et al.(2010)
GM12878-Tcf12_GSE32465
0.886 0.923
TCF12
M09858_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HEB_Q6
0.886 0.923
TCF12
M09859_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HTF4_Q2
0.886 0.923
TCF12
M09860_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TCF12_01
0.886 0.923
TCF12
M09861_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TCF12_03
0.886 0.923
TCF12
M09862_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TCF12_05
0.886 0.923
TCF12
M04138_2.00
Homo sapiens
NCAYCTGN

NCAGRTGN
SELEX
Yin et al.(2017)
TCF12_eDBD_Methyl-HT-SELEX
0.886 0.923
Tcf3
M00753_2.00
Mus musculus
VCACCTGBN

NVCAGGTGB
PBM
Weirauch et al.(2013)
pTH3866
0.886 0.846
Tcf3
M01723_2.00
Mus musculus
NNVCACSTGB

VCASGTGBNN
PBM
Weirauch et al.(2014)
pTH4580
0.886 0.846
Tcf3
M00118_2.00
Mus musculus
VCAYCTGB

VCAGRTGB
PBM
Badis et al.(2009)
Tcfe2a_3865
0.886 0.846
Tcf4
M01750_2.00
Mus musculus
VCAGVTGBN

NVCABCTGB
PBM
Weirauch et al.(2014)
pTH5101
0.884 0.885
TCF4
M02807_2.00
Homo sapiens
HRCACCTGBN

NVCAGGTGYD
SELEX
Jolma et al.(2013)
TCF4_1
0.884 0.885
TCF4
M02808_2.00
Homo sapiens
NVCACCTBBN

NVVAGGTGBN
SELEX
Jolma et al.(2013)
TCF4_2
0.884 0.885
TCF4
M02728_2.00
Homo sapiens
RCACCTG

CAGGTGY
SELEX
Jolma et al.(2010)
TCF4_dimer
0.884 0.885
TCF4
M04214_2.00
Homo sapiens
VCACCTGB

VCAGGTGB
SELEX
Yin et al.(2017)
TCF4_eDBD_HT-SELEX
0.884 0.885
Tcf4
M08775_2.00
Mus musculus
HRCACCTGB

VCAGGTGYD
Misc
Kulakovskiy et al.(2013)
ITF2_MOUSE.H11MO.0.B
0.884 0.885
TCF4
M09461_2.00
Homo sapiens
ASWTCAAAGRVN

NBYCTTTGAWST
Misc
Heinz et al.(2010)
Hct116-Tcf4_SRA012054
0.884 0.885
TCF4
M04215_2.00
Homo sapiens
VCACCTGN

NCAGGTGB
SELEX
Yin et al.(2017)
TCF4_eDBD_Methyl-HT-SELEX
0.884 0.885
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000378813 bHLH 454 507

Links

Other bHLH family TFs
Other Macaca fascicularis TFs

208 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSAMEG00000002108 Ailuropoda melanoleuca ENSAMEG00000002108 I 0.000
ENSAMEG00000005284 Ailuropoda melanoleuca ENSAMEG00000005284 I 0.000
Alligator_sinensis_CCG015050.1 Alligator sinensis Alligator_sinensis_CCG015050.1 I 0.000
Alligator_sinensis_CCG020804.1 Alligator sinensis Alligator_sinensis_CCG020804.1 N 0.000
Alligator_sinensis_CCG001515.1 Alligator sinensis Alligator_sinensis_CCG001515.1 I 0.000
ENSAPLG00000012157 Anas platyrhynchos ENSAPLG00000012157 I 0.000
ENSAPLG00000015648 Anas platyrhynchos ENSAPLG00000015648 I 0.000
TFCP2L1 Anolis carolinensis ENSACAG00000004268 I 0.000
TFCP2 Anolis carolinensis ENSACAG00000012289 I 0.000
Afo_R010616 Aptenodytes forsteri Afo_R010616 I 0.000
Afo_R006827 Aptenodytes forsteri Afo_R006827 I 0.000
ENSAMXG00000016608 Astyanax mexicanus ENSAMXG00000016608 I 0.000
ENSP00000283628-D2 Bos grunniens ENSP00000283628-D2 I 0.000
TFCP2 Bos taurus ENSBTAG00000019312 I 0.000
TFCP2L1 Bos taurus ENSBTAG00000007765 I 0.000
Brh_R004848 Buceros rhinoceros Brh_R004848 I 0.000
TFCP2 Callithrix jacchus ENSCJAG00000017599 I 0.000
Aan_R003641 Calypte anna Aan_R003641 I 0.000
Aan_R009566 Calypte anna Aan_R009566 I 0.000
TFCP2 Canis familiaris ENSCAFG00000007831 I 0.000
TFCP2L1 Canis familiaris ENSCAFG00000004788 I 0.000
TFCP2 Cavia porcellus ENSCPOG00000007923 I 0.000
TFCP2L1 Cavia porcellus ENSCPOG00000011523 I 0.000
Cmyd_10009085 Chelonia mydas Cmyd_10009085 I 0.000
Cmyd_10002729 Chelonia mydas Cmyd_10002729 I 0.000
ENSCSAG00000016679 Chlorocebus sabaeus ENSCSAG00000016679 I 0.000
ENSCSAG00000005909 Chlorocebus sabaeus ENSCSAG00000005909 I 0.000
tfcp2 Danio rerio ENSDARG00000060306 I 0.000
ENSDNOG00000017309 Dasypus novemcinctus ENSDNOG00000017309 I 0.000
TFCP2L1 Equus caballus ENSECAG00000024837 I 0.000
TFCP2 Equus caballus ENSECAG00000020650 I 0.000
ENSECAG00000023454 Equus caballus ENSECAG00000023454 I 0.000
TFCP2 Felis catus ENSFCAG00000030292 I 0.000
ENSFCAG00000023653 Felis catus ENSFCAG00000023653 N 0.000
ENSFALG00000013230 Ficedula albicollis ENSFALG00000013230 I 0.000
ENSGMOG00000010354 Gadus morhua ENSGMOG00000010354 I 0.000
TFCP2L1 Gallus gallus ENSGALG00000011635 I 0.000
ENSGALG00000002235 Gallus gallus ENSGALG00000002235 D 0.000
tfcp2 Gasterosteus aculeatus ENSGACG00000010929 I 0.000
ubp1 Gasterosteus aculeatus ENSGACG00000005520 I 0.000
Gfo_R001211 Geospiza fortis Gfo_R001211 I 0.000
Gfo_R015659 Geospiza fortis Gfo_R015659 I 0.000
TFCP2L1 Gorilla gorilla ENSGGOG00000001680 I 0.000
ENSGGOG00000023919 Gorilla gorilla ENSGGOG00000023919 I 0.000
TFCP2L1 Homo sapiens ENSG00000115112 D 0.000
TFCP2 Homo sapiens ENSG00000135457 D 0.000
ENSSTOG00000013080 Ictidomys tridecemlineatus ENSSTOG00000013080 I 0.000
ENSSTOG00000012083 Ictidomys tridecemlineatus ENSSTOG00000012083 I 0.000
ENSSTOG00000009123 Ictidomys tridecemlineatus ENSSTOG00000009123 I 0.000
ENSLACG00000012609 Latimeria chalumnae ENSLACG00000012609 I 0.000
ENSLOCG00000002718 Lepisosteus oculatus ENSLOCG00000002718 I 0.000
TFCP2 Loxodonta africana ENSLAFG00000009123 I 0.000
ENSP00000263707 Macaca fascicularis ENSP00000263707 I 0.000
ENSP00000257915 Macaca fascicularis ENSP00000257915 I 0.000
TFCP2 Macaca mulatta ENSMMUG00000000152 I 0.000
TFCP2L1 Meleagris gallopavo ENSMGAG00000011889 I 0.000
ENSMGAG00000005564 Meleagris gallopavo ENSMGAG00000005564 I 0.000
ENSMICG00000010940 Microcebus murinus ENSMICG00000010940 I 0.000
TFCP2L1 Microcebus murinus ENSMICG00000007161 I 0.000
TFCP2L1 Monodelphis domestica ENSMODG00000000229 I 0.000
ENSMPUG00000000711 Mustela putorius furo ENSMPUG00000000711 I 0.000
Tfcp2 Mus musculus ENSMUSG00000009733 I 0.000
Tcfcp2l1 Mus musculus ENSMUSG00000026380 D 0.000
Myotis_brandtii_TFCP2_10023086 Myotis brandtii Myotis_brandtii_TFCP2_10023086 I 0.000
TFCP2 Myotis lucifugus ENSMLUG00000013918 I 0.000
ENSNLEG00000000988 Nomascus leucogenys ENSNLEG00000000988 I 0.000
ENSNLEG00000017779 Nomascus leucogenys ENSNLEG00000017779 I 0.000
TFCP2 Ochotona princeps ENSOPRG00000005747 I 0.000
Ogr17000 Ophisaurus gracilis Ogr17000 I 0.000
Ogr16171 Ophisaurus gracilis Ogr16171 I 0.000
ENSONIG00000002320 Oreochromis niloticus ENSONIG00000002320 I 0.000
ENSOANG00000031853 Ornithorhynchus anatinus ENSOANG00000031853 I 0.000
TFCP2L1 Oryctolagus cuniculus ENSOCUG00000006877 I 0.000
ubp1 Oryzias latipes ENSORLG00000011706 I 0.000
TFCP2L1 Otolemur garnettii ENSOGAG00000012031 I 0.000
TFCP2 Otolemur garnettii ENSOGAG00000007969 I 0.000
ENSOARG00000017390 Ovis aries ENSOARG00000017390 I 0.000
ENSOARG00000013124 Ovis aries ENSOARG00000013124 I 0.000
TFCP2 Pan troglodytes ENSPTRG00000004949 I 0.000
TFCP2L1 Pan troglodytes ENSPTRG00000012415 I 0.000
ENSPANG00000019744 Papio anubis ENSPANG00000019744 I 0.000
ENSPANG00000016702 Papio anubis ENSPANG00000016702 I 0.000
ENSPSIG00000008408 Pelodiscus sinensis ENSPSIG00000008408 I 0.000
ENSPSIG00000015527 Pelodiscus sinensis ENSPSIG00000015527 I 0.000
ENSPSIG00000017477 Pelodiscus sinensis ENSPSIG00000017477 I 0.000
ENSPMAG00000007229 Petromyzon marinus ENSPMAG00000007229 I 0.000
ENSPFOG00000008378 Poecilia formosa ENSPFOG00000008378 I 0.000
Pvit_06471 Pogona vitticeps Pvit_06471 I 0.000
Pvit_07455 Pogona vitticeps Pvit_07455 I 0.000
Pvit_07635 Pogona vitticeps Pvit_07635 I 0.000
Pvit_12019 Pogona vitticeps Pvit_12019 I 0.000
ENSPPYG00000012777 Pongo abelii ENSPPYG00000012777 I 0.000
ENSPPYG00000004522 Pongo abelii ENSPPYG00000004522 I 0.000
TFCP2 Pteropus vampyrus ENSPVAG00000014772 I 0.000
Tfcp2 Rattus norvegicus ENSRNOG00000032395 I 0.000
Tfcp2l1 Rattus norvegicus ENSRNOG00000002414 I 0.000
ENSSHAG00000013877 Sarcophilus harrisii ENSSHAG00000013877 I 0.000
ENSSHAG00000000901 Sarcophilus harrisii ENSSHAG00000000901 I 0.000
ENSSARG00000013877 Sorex araneus ENSSARG00000013877 I 0.000
TFCP2 Sorex araneus ENSSARG00000002127 I 0.000
TFCP2L1 Sus scrofa ENSSSCG00000015732 I 0.000
TFCP2L1 Taeniopygia guttata ENSTGUG00000004573 I 0.000
ENSTGUG00000015251 Taeniopygia guttata ENSTGUG00000015251 I 0.000
ubp1 Takifugu rubripes ENSTRUG00000013570 I 0.000
pou6f1 Takifugu rubripes ENSTRUG00000014900 I 0.000
ENSTSYG00000013882 Tarsius syrichta ENSTSYG00000013882 I 0.000
ubp1 Tetraodon nigroviridis ENSTNIG00000016974 I 0.000
tfcp2 Tetraodon nigroviridis ENSTNIG00000012528 I 0.000
TFCP2 Tursiops truncatus ENSTTRG00000013836 I 0.000
Tal_R011103 Tyto alba Tal_R011103 I 0.000
Tal_R010177 Tyto alba Tal_R010177 I 0.000
TFCP2 Vicugna pacos ENSVPAG00000007617 I 0.000
AAP78771 Xenopus laevis AAP78771 I 0.000
tfcp2l1.S Xenopus laevis XB-GENE-6255174 I 0.000
tfcp2.L Xenopus laevis XB-GENE-865546 I 0.000
tfcp2l1.L Xenopus laevis XB-GENE-997202 I 0.000
AAI06326 Xenopus laevis AAI06326 I 0.000
tfcp2 Xenopus tropicalis XB-GENE-485720 I 0.000
ENSXMAG00000003023 Xiphophorus maculatus ENSXMAG00000003023 I 0.000