ENSP00000393788-D1 (Bos grunniens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00010 (HLH) IPR001092 ENSP00000393788-D1 T047290_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
SOHLH2
M01113_2.00
Homo sapiens
BCACGDRNN

NNYHCGTGV
PBM
Lambert et al.(2019)
pTH11270
0.882 0.920
SOHLH2
M04096_2.00
Homo sapiens
NBCACGTGCN

NGCACGTGVN
SELEX
Yin et al.(2017)
SOHLH2_eDBD_HT-SELEX
0.882 0.920
SOHLH2
M04097_2.00
Homo sapiens
NNMACGWDNN

NNHWCGTKNN
SELEX
Yin et al.(2017)
SOHLH2_eDBD_Methyl-HT-SELEX
0.882 0.920
Sohlh2
M01733_2.00
Mus musculus
NNHNCGTGVN

NBCACGNDNN
PBM
Weirauch et al.(2014)
pTH5058
0.881 0.840
Sohlh2
M09890_2.00
Rattus norvegicus Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TEB1_01
0.881 0.840
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000393788-D1 bHLH 189 238

Links

Other bHLH family TFs
Other Bos grunniens TFs

34 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSOCUG00000017853 Oryctolagus cuniculus ENSOCUG00000017853 I 0.914
ENSTBEG00000014863 Tupaia belangeri ENSTBEG00000014863 I 0.914
ENSSSCG00000026164 Sus scrofa ENSSSCG00000026164 I 0.914
ENSTTRG00000010489 Tursiops truncatus ENSTTRG00000010489 I 0.914
ENSOGAG00000001168 Otolemur garnettii ENSOGAG00000001168 I 0.914
ENSFCAG00000004161 Felis catus ENSFCAG00000004161 I 0.914
ENSBTAG00000018955 Bos taurus ENSBTAG00000018955 I 0.914
ENSCPOG00000012403 Cavia porcellus ENSCPOG00000012403 I 0.914
ENSOARG00000010479 Ovis aries ENSOARG00000010479 I 0.886
ENSOPRG00000004777 Ochotona princeps ENSOPRG00000004777 I 0.884
ENSMPUG00000001856 Mustela putorius furo ENSMPUG00000001856 I 0.882
ENSAMEG00000004619 Ailuropoda melanoleuca ENSAMEG00000004619 I 0.882
ENSPTRG00000005779 Pan troglodytes ENSPTRG00000005779 I 0.882
ENSPPYG00000005276 Pongo abelii ENSPPYG00000005276 I 0.882
ENSSTOG00000012257 Ictidomys tridecemlineatus ENSSTOG00000012257 I 0.882
ENSMICG00000002484 Microcebus murinus ENSMICG00000002484 I 0.882
ENSCSAG00000017881 Chlorocebus sabaeus ENSCSAG00000017881 I 0.882
ENSCJAG00000018188 Callithrix jacchus ENSCJAG00000018188 I 0.882
ENSCAFG00000006206 Canis familiaris ENSCAFG00000006206 I 0.882
ENSECAG00000000201 Equus caballus ENSECAG00000000201 I 0.882
SOHLH2 Homo sapiens ENSG00000120669 D 0.882
ENSMMUP00000001562 Macaca fascicularis ENSMMUP00000001562 I 0.882
ENSGGOG00000002130 Gorilla gorilla ENSGGOG00000002130 I 0.882
CCDC169-SOHLH2 Homo sapiens ENSG00000250709 I 0.882
ENSMMUG00000001172 Macaca mulatta ENSMMUG00000001172 I 0.882
Sohlh2 Mus musculus ENSMUSG00000027794 D 0.881
Sohlh2 Rattus norvegicus ENSRNOG00000038091 D 0.881
ENSSARG00000003728 Sorex araneus ENSSARG00000003728 I 0.871
ENSMODG00000009965 Monodelphis domestica ENSMODG00000009965 I 0.862
ENSTSYG00000004449 Tarsius syrichta ENSTSYG00000004449 I 0.862
ENSSHAG00000013234 Sarcophilus harrisii ENSSHAG00000013234 I 0.862
ENSPVAG00000000423 Pteropus vampyrus ENSPVAG00000000423 I 0.852
ENSNLEG00000001499 Nomascus leucogenys ENSNLEG00000001499 I 0.852
ENSMEUG00000002333 Macropus eugenii ENSMEUG00000002333 I 0.838