|
HHAL003331-PA
(Halyomorpha halys)
bHLH
|
TF Information |
Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
PF00010 (HLH) |
IPR001092 |
HHAL003331-PA |
T051403_2.00 |
Misc (2018-Jan-19) |
NCBI Gene Info:This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016] |
Directly determined binding motifs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
No direct experiments |
|
|
|
|
|
Motifs from related TFs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
HLH106
M03626_2.00 |
Drosophila melanogaster |
RTCACGTGAY |
RTCACGTGAY |
SELEX
Nitta et al.(2015)
HLH106_1
|
0.869
|
0.647
|
HLH106
M03627_2.00 |
Drosophila melanogaster |
NRTCACGCCAYH |
DRTGGCGTGAYN |
SELEX
Nitta et al.(2015)
HLH106_2
|
0.869
|
0.647
|
Srebf2
M01725_2.00 |
Mus musculus |
TSRCGTGA |
TCACGYSA |
PBM
Weirauch et al.(2014)
pTH4327
|
0.846
|
0.686
|
SREBF2
M02811_2.00 |
Homo sapiens |
RTCACGTGAY |
RTCACGTGAY |
SELEX
Jolma et al.(2013)
SREBF2_1
|
0.846
|
0.686
|
SREBF2
M03591_2.00 |
Homo sapiens |
NRTCACVCCAYH |
DRTGGBGTGAYN |
SELEX
Nitta et al.(2015)
SREBF2_1
|
0.846
|
0.686
|
SREBF2
M04219_2.00 |
Homo sapiens |
RTCACGCCAY |
RTGGCGTGAY |
SELEX
Yin et al.(2017)
SREBF2_eDBD_HT-SELEX_1
|
0.846
|
0.686
|
SREBF2
M04220_2.00 |
Homo sapiens |
ATCACGTGAY |
RTCACGTGAT |
SELEX
Yin et al.(2017)
SREBF2_eDBD_HT-SELEX_2
|
0.846
|
0.686
|
SREBF2
M08059_2.00 |
Homo sapiens |
RTCACVCCAB |
VTGGBGTGAY |
ChIP-seq
Mathelier et al.(2014)
MA0596.1
|
0.846
|
0.686
|
SREBF2
M08741_2.00 |
Homo sapiens |
NNYCWSBCCABBB |
VVVTGGVSWGRNN |
Misc
Kulakovskiy et al.(2013)
SRBP2_HUMAN.H11MO.0.B
|
0.846
|
0.686
|
Srebf2
M08752_2.00 |
Mus musculus |
NNYCWSBCCABBB |
VVVTGGVSWGRNN |
Misc
Kulakovskiy et al.(2013)
SRBP2_MOUSE.H11MO.0.B
|
0.846
|
0.686
|
SREBF2
M09462_2.00 |
Homo sapiens |
MNRTCACVCCAC |
GTGGBGTGAYNK |
Misc
Heinz et al.(2010)
HepG2-Srebp2_GSE31477
|
0.846
|
0.686
|
SREBF2
M09882_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SREBP2_Q6_01
|
0.846
|
0.686
|
SREBF2
M09883_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SREBP2_Q6
|
0.846
|
0.686
|
SREBF2
M04221_2.00 |
Homo sapiens |
RTCACVCCAY |
RTGGBGTGAY |
SELEX
Yin et al.(2017)
SREBF2_eDBD_Methyl-HT-SELEX_1
|
0.846
|
0.686
|
SREBF2
M04222_2.00 |
Homo sapiens |
RTCACSTGAY |
RTCASGTGAY |
SELEX
Yin et al.(2017)
SREBF2_eDBD_Methyl-HT-SELEX_2
|
0.846
|
0.686
|
SREBF1
M04062_2.00 |
Homo sapiens |
VHCACVCSAY |
RTSGBGTGDB |
SELEX
Yin et al.(2017)
SREBF1_eDBD_HT-SELEX_1
|
0.845
|
0.686
|
SREBF1
M04063_2.00 |
Homo sapiens |
VHCRCGYGDB |
VHCRCGYGDB |
SELEX
Yin et al.(2017)
SREBF1_eDBD_HT-SELEX_2
|
0.845
|
0.686
|
SREBF1
M08048_2.00 |
Homo sapiens |
VTCACSCCAY |
RTGGSGTGAB |
ChIP-seq
Mathelier et al.(2014)
MA0595.1
|
0.845
|
0.686
|
SREBF1
M08711_2.00 |
Homo sapiens |
VTCACVYSAYH |
DRTSRBGTGAB |
Misc
Kulakovskiy et al.(2013)
SRBP1_HUMAN.H11MO.0.A
|
0.845
|
0.686
|
SREBF1
M09796_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SREBF1_02
|
0.845
|
0.686
|
SREBF1
M09797_2.00 |
Homo sapiens |
NATCACGTGAB |
VTCACGTGATN |
Transfac
Matys et al.(2006)
V$SREBP1_01
|
0.845
|
0.686
|
SREBF1
M09798_2.00 |
Homo sapiens |
KRTCACCCCAC |
GTGGGGTGAYM |
Transfac
Matys et al.(2006)
V$SREBP1_02
|
0.845
|
0.686
|
SREBF1
M09799_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SREBP1_Q5
|
0.845
|
0.686
|
SREBF1
M09800_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SREBP1_Q6_01
|
0.845
|
0.686
|
SREBF1
M09801_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SREBP1_Q6
|
0.845
|
0.686
|
SREBF1
M04064_2.00 |
Homo sapiens |
MTCACVCCAY |
RTGGBGTGAK |
SELEX
Yin et al.(2017)
SREBF1_eDBD_Methyl-HT-SELEX_1
|
0.845
|
0.686
|
SREBF1
M04065_2.00 |
Homo sapiens |
RTCACCTGAY |
RTCAGGTGAY |
SELEX
Yin et al.(2017)
SREBF1_eDBD_Methyl-HT-SELEX_2
|
0.845
|
0.686
|
Srebf1
M00754_2.00 |
Mus musculus |
VWCAYVYSAB |
VTSRBRTGWB |
PBM
Weirauch et al.(2013)
pTH0914
|
0.845
|
0.667
|
Srebf1
M01724_2.00 |
Mus musculus |
RWCAYVYBD |
HVRBRTGWY |
PBM
Weirauch et al.(2014)
pTH5161
|
0.845
|
0.667
|
Srebf1
M02816_2.00 |
Mus musculus |
RTCACGTGAY |
RTCACGTGAY |
SELEX
Jolma et al.(2013)
Srebf1_1
|
0.845
|
0.667
|
Srebf1
M08749_2.00 |
Mus musculus |
VTCASSYSABN |
NVTSRSSTGAB |
Misc
Kulakovskiy et al.(2013)
SRBP1_MOUSE.H11MO.0.B
|
0.845
|
0.667
|
For this family, TFs with SR scores > 0.838 will likely have a similar motif |