MGA (Homo sapiens)
bHLH,T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH)
PF00907 (T-box) 		IPR001092
IPR001699 		ENSG00000174197 T055457_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Part of MLL1 complex. [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
MGA
M02821_2.00		 Homo sapiens
RGGTGTGA
TCACACCY		 SELEX
Jolma et al.(2013)
MGA_1		 (Direct) (Direct)
MGA
M02822_2.00		 Homo sapiens
AGGTGTKAHDTMACACCT
AGGTGTKAHDTMACACCT		 SELEX
Jolma et al.(2013)
MGA_2		 (Direct) (Direct)
MGA
M02823_2.00		 Homo sapiens
VGTGTKAWWWTTCACRCB
VGYGTGAAWWWTMACACB		 SELEX
Jolma et al.(2013)
MGA_3		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000219905 T-box 77 260
ENSP00000219905 bHLH 2424 2475
ENSP00000442467 T-box 77 260
ENSP00000442467 bHLH 2215 2266
ENSP00000455155 T-box 77 260
ENSP00000456141 T-box 77 260
ENSP00000456141 bHLH 2215 2266
ENSP00000457035 T-box 77 260
ENSP00000457035 bHLH 2424 2475
ENSP00000457151 T-box 77 260
ENSP00000457474 bHLH 1072 1123

Links

Other bHLH,T-box family TFs
Other Homo sapiens TFs

66 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSPPYG00000006380 Pongo abelii ENSPPYG00000006380 I 1.000
MGA Pan troglodytes ENSPTRG00000006953 I 1.000
MGA Gorilla gorilla ENSGGOG00000001640 I 1.000
ENSP00000219905 Macaca fascicularis ENSP00000219905 I 1.000
ENSNLEG00000003750 Nomascus leucogenys ENSNLEG00000003750 I 1.000
ENSCSAG00000007832 Chlorocebus sabaeus ENSCSAG00000007832 I 1.000
MGA Callithrix jacchus ENSCJAG00000020688 I 0.996
MGA Tupaia belangeri ENSTBEG00000002010 I 0.996
ENSTSYG00000014605 Tarsius syrichta ENSTSYG00000014605 I 0.996
MGA Otolemur garnettii ENSOGAG00000016028 I 0.991
MGA Tursiops truncatus ENSTTRG00000002514 I 0.991
ENSOARG00000020404 Ovis aries ENSOARG00000020404 I 0.991
ENSMPUG00000008968 Mustela putorius furo ENSMPUG00000008968 I 0.991
MGA Microcebus murinus ENSMICG00000001788 I 0.991
MGA Canis familiaris ENSCAFG00000009662 I 0.991
MGA Felis catus ENSFCAG00000007347 I 0.991
ENSAMEG00000016587 Ailuropoda melanoleuca ENSAMEG00000016587 I 0.991
MGA Pteropus vampyrus ENSPVAG00000013732 I 0.991
MGA Equus caballus ENSECAG00000006544 I 0.991
MGA Sorex araneus ENSSARG00000007043 I 0.991
MGA Myotis lucifugus ENSMLUG00000015227 I 0.987
MGA Vicugna pacos ENSVPAG00000006239 I 0.987
ENSSTOG00000000653 Ictidomys tridecemlineatus ENSSTOG00000000653 I 0.987
ENSP00000219905-D1 Bos grunniens ENSP00000219905-D1 I 0.987
MGA Oryctolagus cuniculus ENSOCUG00000006505 I 0.987
MGA Bos taurus ENSBTAG00000015138 I 0.987
MGA Choloepus hoffmanni ENSCHOG00000012044 I 0.987
MGA Erinaceus europaeus ENSEEUG00000004604 I 0.983
Mga Rattus norvegicus ENSRNOG00000006378 I 0.974
Mga Mus musculus ENSMUSG00000033943 I 0.974
MGA Monodelphis domestica ENSMODG00000000052 I 0.940
MGA Procavia capensis ENSPCAG00000013131 I 0.932
Cmyd_10013542 Chelonia mydas Cmyd_10013542 I 0.927
ENSMMUG00000010294 Macaca mulatta ENSMMUG00000010294 N 0.920
MGA Meleagris gallopavo ENSMGAG00000011293 I 0.919
Afo_R002341 Aptenodytes forsteri Afo_R002341 I 0.915
ENSPSIG00000000330 Pelodiscus sinensis ENSPSIG00000000330 N 0.915
ENSPSIG00000004501 Pelodiscus sinensis ENSPSIG00000004501 N 0.915
Alligator_sinensis_CCG001030.1 Alligator sinensis Alligator_sinensis_CCG001030.1 N 0.915
ENSMEUG00000005571 Macropus eugenii ENSMEUG00000005571 N 0.914
MGA Loxodonta africana ENSLAFG00000012978 N 0.914
MGA Sus scrofa ENSSSCG00000004739 N 0.914
ENSDNOG00000032105 Dasypus novemcinctus ENSDNOG00000032105 N 0.914
ENSSSCG00000027182 Sus scrofa ENSSSCG00000027182 N 0.914
MGA Macaca mulatta ENSMMUG00000010168 N 0.914
MGA Cavia porcellus ENSCPOG00000015345 N 0.914
ENSPANG00000018801 Papio anubis ENSPANG00000018801 N 0.914
Gfo_R014126 Geospiza fortis Gfo_R014126 I 0.910
Myotis_brandtii_MGA_10023843 Myotis brandtii Myotis_brandtii_MGA_10023843 I 0.910
ENSGALG00000008653 Gallus gallus ENSGALG00000008653 I 0.910
MGA Ornithorhynchus anatinus ENSOANG00000004502 I 0.906
Ogr06446 Ophisaurus gracilis Ogr06446 I 0.906
ENSFALG00000006030 Ficedula albicollis ENSFALG00000006030 I 0.906
Tal_R011609 Tyto alba Tal_R011609 N 0.902
MGA Ochotona princeps ENSOPRG00000003327 N 0.902
ENSAPLG00000010304 Anas platyrhynchos ENSAPLG00000010304 I 0.897
Mga Dipodomys ordii ENSDORG00000013098 N 0.891
Aan_R008874 Calypte anna Aan_R008874 I 0.889
Ogr06445 Ophisaurus gracilis Ogr06445 N 0.880
Pvit_03503 Pogona vitticeps Pvit_03503 I 0.880
ENSACAG00000014307 Anolis carolinensis ENSACAG00000014307 N 0.864
ENSLACG00000002619 Latimeria chalumnae ENSLACG00000002619 I 0.859
XP_002933783 Xenopus tropicalis XP_002933783 I 0.838
ENSAMXG00000000314 Astyanax mexicanus ENSAMXG00000000314 N 0.792
ENSLOCG00000011689 Lepisosteus oculatus ENSLOCG00000011689 I 0.769