MGA (Homo sapiens)
bHLH,T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH)
PF00907 (T-box) 		IPR001092
IPR001699 		ENSG00000174197 T055457_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Part of MLL1 complex. [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
MGA
M02821_2.00		 Homo sapiens
RGGTGTGA
TCACACCY		 SELEX
Jolma et al.(2013)
MGA_1		 (Direct) (Direct)
MGA
M02822_2.00		 Homo sapiens
AGGTGTKAHDTMACACCT
AGGTGTKAHDTMACACCT		 SELEX
Jolma et al.(2013)
MGA_2		 (Direct) (Direct)
MGA
M02823_2.00		 Homo sapiens
VGTGTKAWWWTTCACRCB
VGYGTGAAWWWTMACACB		 SELEX
Jolma et al.(2013)
MGA_3		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000219905 T-box 77 260
ENSP00000219905 bHLH 2424 2475
ENSP00000442467 T-box 77 260
ENSP00000442467 bHLH 2215 2266
ENSP00000455155 T-box 77 260
ENSP00000456141 T-box 77 260
ENSP00000456141 bHLH 2215 2266
ENSP00000457035 T-box 77 260
ENSP00000457035 bHLH 2424 2475
ENSP00000457151 T-box 77 260
ENSP00000457474 bHLH 1072 1123

Links

Other bHLH,T-box family TFs
Other Homo sapiens TFs

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66 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action