Mga (Mus musculus)
bHLH,T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH)
PF00907 (T-box) 		IPR001092
IPR001699 		ENSMUSG00000033943 T055467_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to leukemia inhibitory factor. Part of transcription regulator complex. Is expressed in several structures, including genitourinary system; gut; heart; nervous system; and sensory organ. Orthologous to human MGA (MAX dimerization protein MGA). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
MGA
M02821_2.00 		Homo sapiens
RGGTGTGA
TCACACCY		 SELEX
Jolma et al.(2013)
MGA_1 		0.974 0.974
MGA
M02822_2.00 		Homo sapiens
AGGTGTKAHDTMACACCT
AGGTGTKAHDTMACACCT		 SELEX
Jolma et al.(2013)
MGA_2 		0.974 0.974
MGA
M02823_2.00 		Homo sapiens
VGTGTKAWWWTTCACRCB
VGYGTGAAWWWTMACACB		 SELEX
Jolma et al.(2013)
MGA_3 		0.974 0.974
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000043795 T-box 77 260
ENSMUSP00000043795 bHLH 2363 2414
ENSMUSP00000078853 T-box 77 260
ENSMUSP00000078853 bHLH 2193 2244
ENSMUSP00000106400 T-box 77 260
ENSMUSP00000106400 bHLH 2284 2335
ENSMUSP00000106401 T-box 77 260
ENSMUSP00000106401 bHLH 2402 2453
ENSMUSP00000119044 T-box 77 260
ENSMUSP00000119044 bHLH 2193 2244

Links

Other bHLH,T-box family TFs
Other Mus musculus TFs

Invalid Input OrderBy

47 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action