snap_masked-nMf.1.1.scaf42701-processed-gene-0.2 (Meloidogyne floridensis)
Brinker

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF09607 (BrkDBD) IPR018586 snap_masked-nMf.1.1.scaf42701-processed-gene-0.2 T055935_2.00 WormBase:ParaSite (2015-Oct-22)
NCBI Gene Info:
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasng blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Aug 2017]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
snap_masked-nMf.1.1.scaf42701-processed-gene-0.2-mRNA-1 Brinker 23 74

Links

Other Brinker family TFs
Other Meloidogyne floridensis TFs

13 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Minc08655 Meloidogyne incognita Minc08655 N 1.000
Minc03820 Meloidogyne incognita Minc03820 N 0.981
MhA1_Contig468.frz3.gene12 Meloidogyne hapla MhA1_Contig468.frz3.gene12 N 0.981
GPLIN_000992900 Globodera pallida GPLIN_000992900 N 0.808
L893_g17711 Steinernema glaseri L893_g17711 N 0.788
L898_g18025 Steinernema monticolum L898_g18025 N 0.769
L889_g9935 Steinernema feltiae L889_g9935 N 0.769
L892_g11291 Steinernema scapterisci L892_g11291 N 0.765
BXY_0367500 Bursaphelenchus xylophilus BXY_0367500 N 0.745
TCLT_0000958101 Thelazia callipaeda TCLT_0000958101 N 0.725
OFLC_0000276401 Onchocerca flexuosa OFLC_0000276401 N 0.712
WBGene00242919 Onchocerca volvulus WBGene00242919 N 0.712
DME_0000033301 Dracunculus medinensis DME_0000033301 N 0.708