CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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XBP1
(
Homo sapiens
)
bZIP
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00170 (bZIP_1)
IPR011616
ENSG00000100219
T059725_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
XBP1
M02730_2.00
Homo sapiens
GACGTGKCNNW
WNNGMCACGTC
SELEX
Jolma et al.(2010)
XBP1_monomer
(Direct)
(Direct)
XBP1
M02825_2.00
Homo sapiens
GVTGACGTCABB
VVTGACGTCABC
SELEX
Jolma et al.(2013)
XBP1_1
(Direct)
(Direct)
XBP1
M02826_2.00
Homo sapiens
GVTGACGTGKCVHW
WDBGMCACGTCABC
SELEX
Jolma et al.(2013)
XBP1_2
(Direct)
(Direct)
XBP1
M04010_2.00
Homo sapiens
GRTGACGTGKCV
BGMCACGTCAYC
SELEX
Rodriguez-Martinez et al.(2017)
XBP1.1
(Direct)
(Direct)
XBP1
M04011_2.00
Homo sapiens
GRTGACGTCAYS
SRTGACGTCAYC
SELEX
Rodriguez-Martinez et al.(2017)
XBP1.2
(Direct)
(Direct)
XBP1
M04012_2.00
Homo sapiens
KGMCACGTGKMCH
DGKMCACGTGKCM
SELEX
Rodriguez-Martinez et al.(2017)
XBP1.3
(Direct)
(Direct)
XBP1
M04231_2.00
Homo sapiens
NVTGACGTGKNN
NNMCACGTCABN
SELEX
Yin et al.(2017)
XBP1_FL_HT-SELEX_1
(Direct)
(Direct)
XBP1
M04232_2.00
Homo sapiens
NVTKACGTMABV
BVTKACGTMABN
SELEX
Yin et al.(2017)
XBP1_FL_HT-SELEX_2
(Direct)
(Direct)
XBP1
M04233_2.00
Homo sapiens
BKMCACRTCAYS
SRTGAYGTGKMV
SELEX
Yin et al.(2017)
XBP1_FL_Methyl-HT-SELEX_1
(Direct)
(Direct)
XBP1
M04234_2.00
Homo sapiens
VVTGWCRTCAYS
SRTGAYGWCABB
SELEX
Yin et al.(2017)
XBP1_FL_Methyl-HT-SELEX_2
(Direct)
(Direct)
XBP1
M09932_2.00
Homo sapiens
NHNWDHRVTGACGTGKHNHWDDHB
VDHHWDNDMCACGTCABYDHWNDN
Transfac
Matys et al.(2006)
V$HTF_01
(Direct)
(Direct)
XBP1
M09933_2.00
Homo sapiens
DBRHTKACGTGKHNHWD
HWDNDMCACGTMADYVH
Transfac
Matys et al.(2006)
V$XBP1_01
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Xbp1
M00757_2.00
Mus musculus
NNHBAYDNNN
NNNHRTVDNN
PBM
Weirauch et al.(2013)
pTH2852
0.831
0.857
Xbp1
M01802_2.00
Mus musculus
NHNACGYNN
NNRCGTNDN
PBM
Weirauch et al.(2014)
pTH5019
0.831
0.857
Xbp1
M08818_2.00
Mus musculus
GACGTGKCMHWD
HWDKGMCACGTC
Misc
Kulakovskiy et al.(2013)
XBP1_MOUSE.H11MO.0.C
0.831
0.857
For this family, TFs with SR scores >
0.782
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000216037
bZIP
68
131
SPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEENQKLLLENQLLREKTHGLVVENQ
ENSP00000343155
bZIP
68
131
SPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEENQKLLLENQLLREKTHGLVVENQ
ENSP00000384295
bZIP
19
81
QPLNSDMRKLKNRVAAQTARDRKKARMSELEQQVVDLEEENQKLLLENQLLREKTHGLVVENQ
ENSP00000385162
bZIP
68
142
SPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEEVKLLKNQKLLLENQLLREKTHGLVVENQELRQRL
ENSP00000481170
bZIP
68
131
SPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEENQKLLLENQLLREKTHGLVVENQ
Links
Other
bZIP
family TFs
Other
Homo sapiens
TFs
59 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy