CIS-BP Database: Catalog of Inferred Sequence Binding Preferences - Update
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CREB3
(
Homo sapiens
)
bZIP
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00170 (bZIP_1)
IPR011616
ENSG00000107175
T059727_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
CREB3
M02829_2.00
Homo sapiens
NNRTGACGTCAYCV
BGRTGACGTCAYNN
SELEX
Jolma et al.(2013)
CREB3_1
(Direct)
(Direct)
CREB3
M02830_2.00
Homo sapiens
NDRTGACGTGKMVN
NBKMCACGTCAYHN
SELEX
Jolma et al.(2013)
CREB3_2
(Direct)
(Direct)
CREB3
M04014_2.00
Homo sapiens
GRTGACGTGGMV
BKCCACGTCAYC
SELEX
Rodriguez-Martinez et al.(2017)
CREB3.1
(Direct)
(Direct)
CREB3
M04015_2.00
Homo sapiens
VRTGACGTCACB
VGTGACGTCAYB
SELEX
Rodriguez-Martinez et al.(2017)
CREB3.2
(Direct)
(Direct)
CREB3
M04239_2.00
Homo sapiens
NRTGACGTGKHN
NDMCACGTCAYN
SELEX
Yin et al.(2017)
CREB3_FL_HT-SELEX_1
(Direct)
(Direct)
CREB3
M04240_2.00
Homo sapiens
NDMCACGTGGYN
NRCCACGTGKHN
SELEX
Yin et al.(2017)
CREB3_FL_HT-SELEX_2
(Direct)
(Direct)
CREB3
M04241_2.00
Homo sapiens
NRTGACGTCAYN
NRTGACGTCAYN
SELEX
Yin et al.(2017)
CREB3_FL_HT-SELEX_3
(Direct)
(Direct)
CREB3
M04242_2.00
Homo sapiens
NKMSACGTSGCV
BGCSACGTSKMN
SELEX
Yin et al.(2017)
CREB3_FL_Methyl-HT-SELEX_1
(Direct)
(Direct)
CREB3
M04243_2.00
Homo sapiens
YKCCACRTCAYM
KRTGAYGTGGMR
SELEX
Yin et al.(2017)
CREB3_FL_Methyl-HT-SELEX_2
(Direct)
(Direct)
CREB3
M04244_2.00
Homo sapiens
NRTGACRTCAYH
DRTGAYGTCAYN
SELEX
Yin et al.(2017)
CREB3_FL_Methyl-HT-SELEX_3
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Creb3
M10030_2.00
Mus musculus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$LUMAN_01
0.825
0.906
For this family, TFs with SR scores >
0.782
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000342136
bZIP
148
211
EQILKRVRRKIRNKRSAQESRRKKKVYVGGLESRVLKYTAQNMELQNKVQLLEEQNLSLLDQLR
ENSP00000484327
bZIP
171
234
EQILKRVRRKIRNKRSAQESRRKKKVYVGGLESRVLKYTAQNMELQNKVQLLEEQNLSLLDQLR
Links
Other
bZIP
family TFs
Other
Homo sapiens
TFs
76 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
ENSNLEG00000004179
Nomascus leucogenys
ENSNLEG00000004179
I
0.870
CREB3
Dasypus novemcinctus
ENSDNOG00000041334
I
0.849
Cmyd_10002091
Chelonia mydas
Cmyd_10002091
I
0.845
Alligator_sinensis_CCG007409.1
Alligator sinensis
Alligator_sinensis_CCG007409.1
I
0.840
Afo_R001188
Aptenodytes forsteri
Afo_R001188
I
0.829
ENSGALG00000002523
Gallus gallus
ENSGALG00000002523
I
0.829
Creb3
Mus musculus
ENSMUSG00000028466
D
0.825
ENSSARG00000004160
Sorex araneus
ENSSARG00000004160
I
0.820
creb3l3l
Tetraodon nigroviridis
ENSTNIG00000016667
I
0.820
Alligator_sinensis_CCG003243.1
Alligator sinensis
Alligator_sinensis_CCG003243.1
I
0.806
ENSFALG00000000900
Ficedula albicollis
ENSFALG00000000900
I
0.806
CREB3L3
Myotis lucifugus
ENSMLUG00000008703
I
0.806
Myotis_brandtii_CREB3L3_10016301
Myotis brandtii
Myotis_brandtii_CREB3L3_10016301
I
0.806
Pvit_09828
Pogona vitticeps
Pvit_09828
I
0.805
creb3
Xenopus tropicalis
XB-GENE-959045
I
0.805
creb3.S
Xenopus laevis
XB-GENE-959048
I
0.801
CREB3L3
Monodelphis domestica
ENSMODG00000000817
I
0.798
ENSMEUG00000013573
Macropus eugenii
ENSMEUG00000013573
I
0.796
ENSAMXG00000011038
Astyanax mexicanus
ENSAMXG00000011038
I
0.795
Alligator_sinensis_CCG001816.1
Alligator sinensis
Alligator_sinensis_CCG001816.1
I
0.793
ENSLOCG00000008658
Lepisosteus oculatus
ENSLOCG00000008658
I
0.792
CREB3L4
Choloepus hoffmanni
ENSCHOG00000002522
I
0.791
ENSLACG00000009185
Latimeria chalumnae
ENSLACG00000009185
I
0.790
Pvit_02332
Pogona vitticeps
Pvit_02332
I
0.789
ENSAMXG00000012038
Astyanax mexicanus
ENSAMXG00000012038
I
0.785
ENSLOCG00000006221
Lepisosteus oculatus
ENSLOCG00000006221
I
0.784
Ogr17869
Ophisaurus gracilis
Ogr17869
I
0.783
ENSSTOG00000012697
Ictidomys tridecemlineatus
ENSSTOG00000012697
I
0.783
CREB3L1
Taeniopygia guttata
ENSTGUG00000010669
I
0.783
CREB3L1
Sus scrofa
ENSSSCG00000013263
I
0.783
CREB3L1
Pteropus vampyrus
ENSPVAG00000016161
I
0.783
Pvit_08659
Pogona vitticeps
Pvit_08659
I
0.783
ENSSHAG00000015230
Sarcophilus harrisii
ENSSHAG00000015230
I
0.783
Myotis_brandtii_CREB3L1_10025503
Myotis brandtii
Myotis_brandtii_CREB3L1_10025503
I
0.783
Gfo_R014160
Geospiza fortis
Gfo_R014160
I
0.783
Afo_R002309
Aptenodytes forsteri
Afo_R002309
I
0.783
Cmyd_10004342
Chelonia mydas
Cmyd_10004342
I
0.783
CREB3L1
Pan troglodytes
ENSPTRG00000003543
I
0.783
ENSP00000288400-D1
Bos grunniens
ENSP00000288400-D1
I
0.783
ENSP00000288400
Macaca fascicularis
ENSP00000288400
I
0.783
CREB3L1
Vicugna pacos
ENSVPAG00000008868
I
0.783
Alligator_sinensis_CCG015770.1
Alligator sinensis
Alligator_sinensis_CCG015770.1
I
0.783
Aan_R008906
Calypte anna
Aan_R008906
I
0.783
CREB3L1
Tursiops truncatus
ENSTTRG00000016515
I
0.783
ENSMPUG00000005639
Mustela putorius furo
ENSMPUG00000005639
I
0.783
CREB3L1
Dasypus novemcinctus
ENSDNOG00000010500
I
0.783
creb3l1
Danio rerio
ENSDARG00000015793
I
0.783
CREB3L1
Equus caballus
ENSECAG00000018306
I
0.783
ENSFALG00000006242
Ficedula albicollis
ENSFALG00000006242
I
0.783
CREB3L1
Homo sapiens
ENSG00000157613
D
0.783
CREB3L1
Felis catus
ENSFCAG00000018794
I
0.783
ENSCSAG00000005658
Chlorocebus sabaeus
ENSCSAG00000005658
I
0.783
CREB3L1
Cavia porcellus
ENSCPOG00000010073
I
0.783
ENSAMXG00000021541
Astyanax mexicanus
ENSAMXG00000021541
I
0.783
ENSAMEG00000006633
Ailuropoda melanoleuca
ENSAMEG00000006633
I
0.783
ENSAPLG00000000926
Anas platyrhynchos
ENSAPLG00000000926
I
0.783
CREB3L1
Bos taurus
ENSBTAG00000006143
I
0.783
CREB3L1
Callithrix jacchus
ENSCJAG00000011726
I
0.783
CREB3L1
Canis familiaris
ENSCAFG00000009282
I
0.783
CREB3L1
Gallus gallus
ENSGALG00000008393
I
0.783
CREB3L1
Gorilla gorilla
ENSGGOG00000015181
I
0.783
CREB3L1
Anolis carolinensis
ENSACAG00000004538
I
0.783
CREB3L1
Monodelphis domestica
ENSMODG00000019888
I
0.783
CREB3L1
Oryctolagus cuniculus
ENSOCUG00000004418
I
0.783
CREB3L1
Otolemur garnettii
ENSOGAG00000008829
I
0.783
ENSPANG00000015384
Papio anubis
ENSPANG00000015384
I
0.783
ENSPSIG00000004461
Pelodiscus sinensis
ENSPSIG00000004461
I
0.783
CREB3L1
Macaca mulatta
ENSMMUG00000018571
I
0.783
CREB3L1
Loxodonta africana
ENSLAFG00000005092
I
0.783
ENSLACG00000007675
Latimeria chalumnae
ENSLACG00000007675
I
0.783
CREB3L1
Myotis lucifugus
ENSMLUG00000009820
I
0.783
ENSLOCG00000005600
Lepisosteus oculatus
ENSLOCG00000005600
I
0.783
CREB3L1
Meleagris gallopavo
ENSMGAG00000011042
I
0.783
Creb3l1
Rattus norvegicus
ENSRNOG00000005413
I
0.782
Creb3l1
Mus musculus
ENSMUSG00000027230
I
0.782