CREB3 (Homo sapiens)
bZIP

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00170 (bZIP_1) IPR011616 ENSG00000107175 T059727_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
CREB3
M02829_2.00
Homo sapiens
NNRTGACGTCAYCV

BGRTGACGTCAYNN
SELEX
Jolma et al.(2013)
CREB3_1
(Direct) (Direct)
CREB3
M02830_2.00
Homo sapiens
NDRTGACGTGKMVN

NBKMCACGTCAYHN
SELEX
Jolma et al.(2013)
CREB3_2
(Direct) (Direct)
CREB3
M04014_2.00
Homo sapiens
GRTGACGTGGMV

BKCCACGTCAYC
SELEX
Rodriguez-Martinez et al.(2017)
CREB3.1
(Direct) (Direct)
CREB3
M04015_2.00
Homo sapiens
VRTGACGTCACB

VGTGACGTCAYB
SELEX
Rodriguez-Martinez et al.(2017)
CREB3.2
(Direct) (Direct)
CREB3
M04239_2.00
Homo sapiens
NRTGACGTGKHN

NDMCACGTCAYN
SELEX
Yin et al.(2017)
CREB3_FL_HT-SELEX_1
(Direct) (Direct)
CREB3
M04240_2.00
Homo sapiens
NDMCACGTGGYN

NRCCACGTGKHN
SELEX
Yin et al.(2017)
CREB3_FL_HT-SELEX_2
(Direct) (Direct)
CREB3
M04241_2.00
Homo sapiens
NRTGACGTCAYN

NRTGACGTCAYN
SELEX
Yin et al.(2017)
CREB3_FL_HT-SELEX_3
(Direct) (Direct)
CREB3
M04242_2.00
Homo sapiens
NKMSACGTSGCV

BGCSACGTSKMN
SELEX
Yin et al.(2017)
CREB3_FL_Methyl-HT-SELEX_1
(Direct) (Direct)
CREB3
M04243_2.00
Homo sapiens
YKCCACRTCAYM

KRTGAYGTGGMR
SELEX
Yin et al.(2017)
CREB3_FL_Methyl-HT-SELEX_2
(Direct) (Direct)
CREB3
M04244_2.00
Homo sapiens
NRTGACRTCAYH

DRTGAYGTCAYN
SELEX
Yin et al.(2017)
CREB3_FL_Methyl-HT-SELEX_3
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Creb3
M10030_2.00
Mus musculus Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$LUMAN_01
0.825 0.906
For this family, TFs with SR scores > 0.782 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000342136 bZIP 148 211
ENSP00000484327 bZIP 171 234

Links

Other bZIP family TFs
Other Homo sapiens TFs

76 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Creb3 Mus musculus ENSMUSG00000028466 D 0.825
CREB3L1 Homo sapiens ENSG00000157613 D 0.783
Pvit_08659 Pogona vitticeps Pvit_08659 I 0.783
CREB3L1 Vicugna pacos ENSVPAG00000008868 I 0.783
CREB3L1 Tursiops truncatus ENSTTRG00000016515 I 0.783
creb3l3l Tetraodon nigroviridis ENSTNIG00000016667 I 0.820
CREB3L1 Taeniopygia guttata ENSTGUG00000010669 I 0.783
ENSSTOG00000012697 Ictidomys tridecemlineatus ENSSTOG00000012697 I 0.783
CREB3L1 Sus scrofa ENSSSCG00000013263 I 0.783
ENSSHAG00000015230 Sarcophilus harrisii ENSSHAG00000015230 I 0.783
ENSSARG00000004160 Sorex araneus ENSSARG00000004160 I 0.820
Creb3l1 Rattus norvegicus ENSRNOG00000005413 I 0.782
CREB3L1 Pteropus vampyrus ENSPVAG00000016161 I 0.783
CREB3L1 Pan troglodytes ENSPTRG00000003543 I 0.783
ENSPSIG00000004461 Pelodiscus sinensis ENSPSIG00000004461 I 0.783
ENSPANG00000015384 Papio anubis ENSPANG00000015384 I 0.783
CREB3L1 Otolemur garnettii ENSOGAG00000008829 I 0.783
CREB3L1 Oryctolagus cuniculus ENSOCUG00000004418 I 0.783
ENSNLEG00000004179 Nomascus leucogenys ENSNLEG00000004179 I 0.870
Aan_R008906 Calypte anna Aan_R008906 I 0.783
creb3 Xenopus tropicalis XB-GENE-959045 I 0.805
Pvit_02332 Pogona vitticeps Pvit_02332 I 0.789
Ogr17869 Ophisaurus gracilis Ogr17869 I 0.783
Myotis_brandtii_CREB3L3_10016301 Myotis brandtii Myotis_brandtii_CREB3L3_10016301 I 0.806
Myotis_brandtii_CREB3L1_10025503 Myotis brandtii Myotis_brandtii_CREB3L1_10025503 I 0.783
Gfo_R014160 Geospiza fortis Gfo_R014160 I 0.783
ENSP00000288400 Macaca fascicularis ENSP00000288400 I 0.783
ENSP00000288400-D1 Bos grunniens ENSP00000288400-D1 I 0.783
Cmyd_10004342 Chelonia mydas Cmyd_10004342 I 0.783
Cmyd_10002091 Chelonia mydas Cmyd_10002091 I 0.845
Alligator_sinensis_CCG015770.1 Alligator sinensis Alligator_sinensis_CCG015770.1 I 0.783
Alligator_sinensis_CCG007409.1 Alligator sinensis Alligator_sinensis_CCG007409.1 I 0.840
Alligator_sinensis_CCG003243.1 Alligator sinensis Alligator_sinensis_CCG003243.1 I 0.806
Alligator_sinensis_CCG001816.1 Alligator sinensis Alligator_sinensis_CCG001816.1 I 0.793
Afo_R002309 Aptenodytes forsteri Afo_R002309 I 0.783
Afo_R001188 Aptenodytes forsteri Afo_R001188 I 0.829
Pvit_09828 Pogona vitticeps Pvit_09828 I 0.805
creb3.S Xenopus laevis XB-GENE-959048 I 0.801
Creb3l1 Mus musculus ENSMUSG00000027230 I 0.782
ENSFALG00000000900 Ficedula albicollis ENSFALG00000000900 I 0.806
CREB3L1 Equus caballus ENSECAG00000018306 I 0.783
CREB3 Dasypus novemcinctus ENSDNOG00000041334 I 0.849
CREB3L1 Dasypus novemcinctus ENSDNOG00000010500 I 0.783
creb3l1 Danio rerio ENSDARG00000015793 I 0.783
ENSCSAG00000005658 Chlorocebus sabaeus ENSCSAG00000005658 I 0.783
CREB3L1 Cavia porcellus ENSCPOG00000010073 I 0.783
CREB3L1 Callithrix jacchus ENSCJAG00000011726 I 0.783
CREB3L4 Choloepus hoffmanni ENSCHOG00000002522 I 0.791
CREB3L1 Canis familiaris ENSCAFG00000009282 I 0.783
CREB3L1 Bos taurus ENSBTAG00000006143 I 0.783
ENSAPLG00000000926 Anas platyrhynchos ENSAPLG00000000926 I 0.783
ENSAMXG00000021541 Astyanax mexicanus ENSAMXG00000021541 I 0.783
ENSAMXG00000012038 Astyanax mexicanus ENSAMXG00000012038 I 0.785
ENSAMXG00000011038 Astyanax mexicanus ENSAMXG00000011038 I 0.795
ENSAMEG00000006633 Ailuropoda melanoleuca ENSAMEG00000006633 I 0.783
ENSFALG00000006242 Ficedula albicollis ENSFALG00000006242 I 0.783
CREB3L1 Felis catus ENSFCAG00000018794 I 0.783
ENSGALG00000002523 Gallus gallus ENSGALG00000002523 I 0.829
ENSMPUG00000005639 Mustela putorius furo ENSMPUG00000005639 I 0.783
CREB3L1 Monodelphis domestica ENSMODG00000019888 I 0.783
CREB3L3 Monodelphis domestica ENSMODG00000000817 I 0.798
CREB3L1 Macaca mulatta ENSMMUG00000018571 I 0.783
CREB3L1 Myotis lucifugus ENSMLUG00000009820 I 0.783
CREB3L3 Myotis lucifugus ENSMLUG00000008703 I 0.806
CREB3L1 Meleagris gallopavo ENSMGAG00000011042 I 0.783
ENSMEUG00000013573 Macropus eugenii ENSMEUG00000013573 I 0.796
ENSLOCG00000008658 Lepisosteus oculatus ENSLOCG00000008658 I 0.792
ENSLOCG00000006221 Lepisosteus oculatus ENSLOCG00000006221 I 0.784
ENSLOCG00000005600 Lepisosteus oculatus ENSLOCG00000005600 I 0.783
CREB3L1 Loxodonta africana ENSLAFG00000005092 I 0.783
ENSLACG00000009185 Latimeria chalumnae ENSLACG00000009185 I 0.790
ENSLACG00000007675 Latimeria chalumnae ENSLACG00000007675 I 0.783
CREB3L1 Gorilla gorilla ENSGGOG00000015181 I 0.783
CREB3L1 Gallus gallus ENSGALG00000008393 I 0.783
CREB3L1 Anolis carolinensis ENSACAG00000004538 I 0.783