|
|
TEF
(Homo sapiens)
bZIP
|
TF Information |
|---|
| Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
Animal TF db |
| PF00170 (bZIP_1) |
IPR011616 |
ENSG00000167074 |
T059752_2.00 |
Ensembl (2018-Dec-8) |
Link out |
| NCBI Gene Info:This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
Directly determined binding motifs |
|---|
| Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR
Score |
DBD
Identity |
TEF
M02849_2.00 |
Homo sapiens |
NRTTAYGTAAYN |
NRTTACRTAAYN |
SELEX
Jolma et al.(2013)
TEF_1 |
(Direct) |
(Direct) |
TEF
M02850_2.00 |
Homo sapiens |
NVTTAYGTAABN |
NVTTACRTAABN |
SELEX
Jolma et al.(2013)
TEF_2 |
(Direct) |
(Direct) |
TEF
M04325_2.00 |
Homo sapiens |
NRTTACGTAAYN |
NRTTACGTAAYN |
SELEX
Yin et al.(2017)
TEF_eDBD_HT-SELEX |
(Direct) |
(Direct) |
TEF
M04326_2.00 |
Homo sapiens |
NRTTACRTAAYN |
NRTTAYGTAAYN |
SELEX
Yin et al.(2017)
TEF_eDBD_Methyl-HT-SELEX |
(Direct) |
(Direct) |
TEF
M09983_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$TEF_05 |
(Direct) |
(Direct) |
TEF
M09984_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$TEF_06 |
(Direct) |
(Direct) |
TEF
M09985_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$TEF_Q6 |
(Direct) |
(Direct) |
TEF
M09986_2.00 |
Homo sapiens |
MTKAYGTAAY |
RTTACRTMAK |
Transfac
Matys et al.(2006)
V$VBP_01 |
(Direct) |
(Direct) |
Motifs from related TFs |
|---|
| Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR
Score |
DBD
Identity |
Tef
M01803_2.00 |
Mus musculus |
NVTTRYVNNN |
NNNBRYAABN |
PBM
Weirauch et al.(2014)
pTH5078
|
0.891
|
1.000
|
HLF
M02831_2.00 |
Homo sapiens |
NRTTAYRTAABN |
NVTTAYRTAAYN |
SELEX
Jolma et al.(2013)
HLF_1
|
0.847
|
0.781
|
Hlf
M02860_2.00 |
Mus musculus |
KRTTACGTAAYN |
NRTTACGTAAYM |
SELEX
Jolma et al.(2013)
Hlf_1
|
0.847
|
0.781
|
HLF
M04245_2.00 |
Homo sapiens |
NVTTRCRYAABN |
NVTTRYGYAABN |
SELEX
Yin et al.(2017)
HLF_FL_HT-SELEX
|
0.847
|
0.781
|
HLF
M04016_2.00 |
Homo sapiens |
RTKAYRTAAB |
VTTAYRTMAY |
SELEX
Rodriguez-Martinez et al.(2017)
HLF.1
|
0.847
|
0.781
|
HLF
M08786_2.00 |
Homo sapiens |
NRTTRYGTAAYMS |
SKRTTACRYAAYN |
Misc
Kulakovskiy et al.(2013)
HLF_HUMAN.H11MO.0.C
|
0.847
|
0.781
|
Hlf
M08815_2.00 |
Mus musculus |
VTTRTGYAABH |
DVTTRCAYAAB |
Misc
Kulakovskiy et al.(2013)
HLF_MOUSE.H11MO.0.C
|
0.847
|
0.781
|
HLF
M09937_2.00 |
Homo sapiens |
ATKRYGTAAY |
RTTACRYMAT |
Transfac
Matys et al.(2006)
V$HLF_01
|
0.847
|
0.781
|
HLF
M04246_2.00 |
Homo sapiens |
NVTTRCRYAABN |
NVTTRYGYAABN |
SELEX
Yin et al.(2017)
HLF_FL_Methyl-HT-SELEX
|
0.847
|
0.781
|
| For this family, TFs with SR scores > 0.782 will likely have a similar motif |