DDIT3 (Homo sapiens)
bZIP

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00170 (bZIP_1) IPR011616 ENSG00000175197 T059758_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
DDIT3
M09999_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CHOP10_01
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Ddit3
M08822_2.00
Mus musculus
MTGATGHAAB

VTTDCATCAK
Misc
Kulakovskiy et al.(2013)
DDIT3_MOUSE.H11MO.0.C
0.890 0.921
Ddit3
M09492_2.00
Mus musculus
MTGATGHAAB

VTTDCATCAK
Misc
Heinz et al.(2010)
MEF-Chop_GSE35681
0.890 0.921
For this family, TFs with SR scores > 0.782 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000340671 bZIP 97 159
ENSP00000447188 bZIP 97 159
ENSP00000447803 bZIP 120 182
ENSP00000448665 bZIP 120 182
ENSP00000481270 bZIP 96 158

Links

Other bZIP family TFs
Other Homo sapiens TFs

28 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Ddit3 Mus musculus ENSMUSG00000025408 D 0.890
DDIT3 Bos taurus ENSBTAG00000031544 I 0.911
DDIT3 Ochotona princeps ENSOPRG00000006529 I 0.881
ENSPANG00000024001 Papio anubis ENSPANG00000024001 I 1.000
DDIT3 Procavia capensis ENSPCAG00000016158 I 0.861
ENSPPYG00000004692 Pongo abelii ENSPPYG00000004692 I 0.994
DDIT3 Pan troglodytes ENSPTRG00000022781 I 1.000
DDIT3 Pteropus vampyrus ENSPVAG00000012114 I 0.815
DDIT3 Sorex araneus ENSSARG00000002536 I 0.880
ENSSSCG00000022482 Sus scrofa ENSSSCG00000022482 I 0.978
ENSSTOG00000019858 Ictidomys tridecemlineatus ENSSTOG00000019858 I 0.822
DDIT3 Tupaia belangeri ENSTBEG00000000521 I 0.911
ENSP00000340671-D1 Bos grunniens ENSP00000340671-D1 I 0.911
DDIT3 Otolemur garnettii ENSOGAG00000005231 I 0.832
ENSOARG00000006500 Ovis aries ENSOARG00000006500 I 0.889
DDIT3 Callithrix jacchus ENSCJAG00000007243 I 0.956
ENSCSAG00000004816 Chlorocebus sabaeus ENSCSAG00000004816 I 1.000
DDIT3 Dasypus novemcinctus ENSDNOG00000017504 I 0.883
DDIT3 Equus caballus ENSECAG00000020535 I 0.889
DDIT3 Erinaceus europaeus ENSEEUG00000003634 I 0.875
DDIT3 Gorilla gorilla ENSGGOG00000001987 I 1.000
DDIT3 Loxodonta africana ENSLAFG00000030970 I 0.839
DDIT3 Microcebus murinus ENSMICG00000005434 I 0.991
DDIT3 Myotis lucifugus ENSMLUG00000001055 I 0.821
DDIT3 Macaca mulatta ENSMMUG00000011286 I 1.000
ENSNLEG00000017291 Nomascus leucogenys ENSNLEG00000017291 I 1.000
ENSP00000340671 Macaca fascicularis ENSP00000340671 I 1.000