DDIT3 (Homo sapiens)
bZIP

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00170 (bZIP_1) IPR011616 ENSG00000175197 T059758_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
DDIT3
M09999_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CHOP10_01
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Ddit3
M08822_2.00
Mus musculus
MTGATGHAAB

VTTDCATCAK
Misc
Kulakovskiy et al.(2013)
DDIT3_MOUSE.H11MO.0.C
0.890 0.921
Ddit3
M09492_2.00
Mus musculus
MTGATGHAAB

VTTDCATCAK
Misc
Heinz et al.(2010)
MEF-Chop_GSE35681
0.890 0.921
For this family, TFs with SR scores > 0.782 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000340671 bZIP 97 159
ENSP00000447188 bZIP 97 159
ENSP00000447803 bZIP 120 182
ENSP00000448665 bZIP 120 182
ENSP00000481270 bZIP 96 158

Links

Other bZIP family TFs
Other Homo sapiens TFs

28 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action